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Lung transplantation from donation after cardiocirculatory death: a systematic review and meta-analysis

医学 荟萃分析 科克伦图书馆 内科学 相对风险 置信区间 肺移植 移植 系统回顾 捐赠 预期寿命 重症监护医学 梅德林 人口 环境卫生 政治学 法学 经济 经济增长
作者
Dustin C. Krutsinger,Robert M. Reed,Amy Blevins,Varun Puri,Nilto C. De Oliveira,B. Zych,Servet Bölükbas,Dirk Van Raemdonck,Gregory I. Snell,Michael Eberlein
出处
期刊:Journal of Heart and Lung Transplantation [Elsevier BV]
卷期号:34 (5): 675-684 被引量:134
标识
DOI:10.1016/j.healun.2014.11.009
摘要

Background Lung transplantation (LTx) can extend life expectancy and enhance the quality of life for select patients with end-stage lung disease. In the setting of donor lung shortage and waiting list mortality, the interest in donation after cardiocirculatory death (DCD) is increasing. We performed a systematic review and meta-analysis to compare outcomes between DCD and conventional donation after brain death (DBD). Methods PubMed, CINAHL, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, and ClinicalTrials.gov were searched. We identified original research studies with 1-year post-transplant survival data involving >5 DCD transplants. We performed meta-analyses examining 1-year survival, primary graft dysfunction, and acute rejection after LTx. Results We identified 519 citations; 11 observational cohort studies met our inclusion criteria for systematic review, and 6 met our inclusion criteria for meta-analysis. There were no differences found in 1-year mortality after LTx between DCD and DBD cohorts in individual studies or in the meta-analysis (DCD [n = 271] vs DBD [n = 2,369], relative risk [RR] 0.88, 95% confidence interval [CI] 0.59–1.31, p = 0.52, I2 = 0%). There was also no difference between DCD and DBD in a pooled analysis of 5 studies reporting on primary graft dysfunction (RR 1.09, 95% CI 0.68–1.73, p = 0.7, I2 = 0%) and 4 studies reporting on acute rejection (RR 0.72, 95% CI 0.49–1.05, p = 0.09, I2 = 0%). Conclusions Survival after LTx from DCD is comparable to survival after LTx from DBD in observational cohort studies. DCD appears to be a safe and effective method to expand the donor pool. Lung transplantation (LTx) can extend life expectancy and enhance the quality of life for select patients with end-stage lung disease. In the setting of donor lung shortage and waiting list mortality, the interest in donation after cardiocirculatory death (DCD) is increasing. We performed a systematic review and meta-analysis to compare outcomes between DCD and conventional donation after brain death (DBD). PubMed, CINAHL, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, and ClinicalTrials.gov were searched. We identified original research studies with 1-year post-transplant survival data involving >5 DCD transplants. We performed meta-analyses examining 1-year survival, primary graft dysfunction, and acute rejection after LTx. We identified 519 citations; 11 observational cohort studies met our inclusion criteria for systematic review, and 6 met our inclusion criteria for meta-analysis. There were no differences found in 1-year mortality after LTx between DCD and DBD cohorts in individual studies or in the meta-analysis (DCD [n = 271] vs DBD [n = 2,369], relative risk [RR] 0.88, 95% confidence interval [CI] 0.59–1.31, p = 0.52, I2 = 0%). There was also no difference between DCD and DBD in a pooled analysis of 5 studies reporting on primary graft dysfunction (RR 1.09, 95% CI 0.68–1.73, p = 0.7, I2 = 0%) and 4 studies reporting on acute rejection (RR 0.72, 95% CI 0.49–1.05, p = 0.09, I2 = 0%). Survival after LTx from DCD is comparable to survival after LTx from DBD in observational cohort studies. DCD appears to be a safe and effective method to expand the donor pool.
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