医学
植入式心律转复除颤器
心内膜炎
心脏再同步化治疗
预防性抗生素
回顾性队列研究
外科
退伍军人事务部
置信区间
抗生素
内科学
心力衰竭
射血分数
生物
微生物学
作者
Heather Bloom,Luis Constantin,DANIEL DAN,David B. De Lurgio,Mikhael F. El‐Chami,Leonard I. Ganz,Kent Gleed,F. Kevin Hackett,Narendra Kanuru,Daniel J. Lerner,Abdi Rasekh,Grant R. Simons,Felix Sogade,M. Rizwan Sohail
标识
DOI:10.1111/j.1540-8159.2010.02931.x
摘要
Background: Cardiovascular implantable electronic device (CIED) infection rates are increasing faster than implantation rates. More effective antimicrobial prophylaxis may help reduce CIED infections and improve clinical outcomes. The AIGIS Rx ® antibacterial envelope is a polymer mesh implanted in the generator pocket with the CIED. After implantation it releases two antibiotics, minocycline and rifampin, that have been shown to reduce infections associated with other medical devices. The purpose of this retrospective cohort study is to determine the rate of CIED implantation success and CIED infection in procedures utilizing the antibacterial envelope. Methods: This study enrolled consecutive CIED procedures utilizing the antibacterial envelope at 10 US academic, community, and Veterans Affairs medical centers. Procedures following an explantation for a prior CIED infection or off‐label use of the antibacterial envelope were excluded. Results: The 624 eligible procedures (age 70 ± 13 years, 68.1% men, 27.2% renal insufficiency, 35.4% oral anticoagulant use, 67.8% replacement/revision procedures) utilized pacemakers (35%), implantable cardioverter‐defibrillators (ICD)(29%), and cardiac resynchronization therapy with defibrillator devices (CRT‐D)(36%). Nearly half of the patients (49%) had at least three predefined risk factors for CIED infection. CIED implantation was successful in 621 procedures (99.5%[95% confidence interval (CI) 98.8–99.9]). There were three major infections (0.48%[95%CI 0.17–1.40]) after 1.9 ± 2.4 months follow‐up. The infections followed one ICD revision and two CRT‐D replacements. There were seven deaths; none was a result of the antibacterial envelope or the CIED procedure. Conclusions: CIED procedures that utilized an antibacterial envelope had a high rate of CIED implantation success (>99%). Although the follow‐up to date is short, there was also a low rate of infection (<0.50%) in this population at high risk for CIED infection. (PACE 2011; 34:133–142)
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