亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

2-weekly versus 3-weekly docetaxel to treat castration-resistant advanced prostate cancer: a randomised, phase 3 trial

多西紫杉醇 医学 前列腺癌 内科学 癌症 泌尿科 随机对照试验 肿瘤科
作者
Pirkko‐Liisa Kellokumpu‐Lehtinen,Ulrika Harmenberg,Timo Joensuu,Ray McDermott,Petteri Hervonen,Claes Ginman,Marjaana Luukkaa,Paul Nyandoto,Akseli Hemminki,Sten Nilsson,John McCaffrey,R. Asola,Taina Turpeenniemi‐Hujanen,Fredrik Laestadius,Tiina Tasmuth,Katinka Sandberg,Maccon Keane,Ilari Lehtinen,Tiina Luukkaala,Heikki Joensuu
出处
期刊:Lancet Oncology [Elsevier BV]
卷期号:14 (2): 117-124 被引量:195
标识
DOI:10.1016/s1470-2045(12)70537-5
摘要

Docetaxel administered every 3 weeks is a standard treatment for castration-resistant advanced prostate cancer. We hypothesised that 2-weekly administration of docetaxel would be better tolerated than 3-weekly docetaxel in patients with castration-resistant advanced prostate cancer, and did a prospective, multicentre, randomised, phase 3 study to compare efficacy and safety.Eligible patients had advanced prostate cancer (metastasis, a prostate-specific-antigen test result of more than 10·0 ng/mL, and WHO performance status score of 0-2), had received no chemotherapy (except with estramustine), had undergone surgical or chemical castration, and had been referred to a treatment centre in Finland, Ireland, or Sweden. Enrolment and treatment were done between March 1, 2004, and May 31, 2009. Randomisation was done centrally and stratified by centre and WHO performance status score of 0-1 vs 2. Patients were assigned 75 mg/m(2) docetaxel intravenously on day 1 of a 3-week cycle, or 50 mg/m(2) docetaxel intravenously on days 1 and 15 of a 4-week cycle. 10 mg oral prednisolone was administered daily to all patients. The primary endpoint was time to treatment failure (TTTF). We assessed data in the per-protocol population. This study is registered with ClinicalTrials.gov, number NCT00255606.177 patients were randomly assigned to the 2-weekly docetaxel group and 184 to the 3-weekly group. 170 patients in the 2-weekly group and 176 in the 3-weekly group were included in the analysis. The 2-weekly administration was associated with significantly longer TTTF than was 3-weekly administration (5·6 months, 95% CI 5·0-6·2 vs 4·9 months, 4·5-5·4; hazard ratio 1·3, 95% CI 1·1-1·6, p=0·014). Grade 3-4 adverse events occurred more frequently in the 3-weekly than in the 2-weekly administration group, including neutropenia (93 [53%] vs 61 [36%]), leucopenia (51 [29%] vs 22 [13%]), and febrile neutropenia (25 [14%] vs six [4%]). Neutropenic infections were reported more frequently in patients who received docetaxel every 3 weeks (43 [24%] vs 11 [6%], p=0·002).Administration of docetaxel every 2 weeks seems to be well tolerated in patients with castration-resistant advanced prostate cancer and could be a useful option when 3-weekly single-dose administration is unlikely to be tolerated.Sanofi.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
mmyhn发布了新的文献求助10
8秒前
19秒前
50秒前
Liiiiiiiiii发布了新的文献求助10
55秒前
三水完成签到 ,获得积分20
1分钟前
小净完成签到 ,获得积分20
1分钟前
cccttt完成签到,获得积分10
1分钟前
mmyhn发布了新的文献求助10
1分钟前
Echo完成签到,获得积分10
1分钟前
无花果应助zzx采纳,获得10
1分钟前
可爱的香菇完成签到 ,获得积分10
1分钟前
1分钟前
dovejingling完成签到,获得积分10
1分钟前
lulu发布了新的文献求助20
1分钟前
Jasper应助科研通管家采纳,获得10
2分钟前
顾矜应助科研通管家采纳,获得10
2分钟前
2分钟前
李沐唅完成签到 ,获得积分10
2分钟前
核桃发布了新的文献求助30
2分钟前
2分钟前
阿凯完成签到 ,获得积分10
2分钟前
zzx发布了新的文献求助10
2分钟前
zzx完成签到,获得积分10
2分钟前
小泉完成签到 ,获得积分10
2分钟前
星辰大海应助高兴的忆曼采纳,获得10
3分钟前
英姑应助核桃采纳,获得10
3分钟前
科研通AI5应助核桃采纳,获得10
3分钟前
科研通AI5应助核桃采纳,获得10
3分钟前
可爱的函函应助核桃采纳,获得10
3分钟前
Liufgui应助核桃采纳,获得10
3分钟前
在水一方应助核桃采纳,获得10
3分钟前
隐形曼青应助科研通管家采纳,获得10
4分钟前
丘比特应助科研通管家采纳,获得10
4分钟前
爆米花应助科研通管家采纳,获得10
4分钟前
LONG完成签到 ,获得积分10
4分钟前
秋风今是完成签到 ,获得积分10
4分钟前
4分钟前
核桃发布了新的文献求助10
4分钟前
biubiubiu驳回了852应助
5分钟前
AUGKING27完成签到 ,获得积分10
5分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990045
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256334
捐赠科研通 3270943
什么是DOI,文献DOI怎么找? 1805146
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228