软骨
软骨发生
再生(生物学)
组织工程
变性(医学)
医学
细胞生物学
生物医学工程
解剖
生物
病理
作者
Maumita Bhattacharjee,Jeannine M. Coburn,Matteo Centola,Sumit Murab,Andrea Barbero,David L. Kaplan,Iván Martín,Sourabh Ghosh
标识
DOI:10.1016/j.addr.2014.08.010
摘要
Cartilage tissue engineering has primarily focused on the generation of grafts to repair cartilage defects due to traumatic injury and disease. However engineered cartilage tissues have also a strong scientific value as advanced 3D culture models. Here we first describe key aspects of embryonic chondrogenesis and possible cell sources/culture systems for in vitro cartilage generation. We then review how a tissue engineering approach has been and could be further exploited to investigate different aspects of cartilage development and degeneration. The generated knowledge is expected to inform new cartilage regeneration strategies, beyond a classical tissue engineering paradigm.
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