胞浆
细胞内
生物能学
生物物理学
平衡
联轴节(管道)
化学
细胞内pH值
三磷酸腺苷
离子键合
ATP水解
磷酸化
生物化学
电生理学
生物
酶
细胞生物学
离子
线粒体
神经科学
材料科学
ATP酶
有机化学
冶金
作者
Anushka Michailova,Andrew D. McCulloch
出处
期刊:PubMed
日期:2008-03-01
卷期号:21 (1): 16-28
被引量:3
摘要
A tight coupling between ionic currents, intracellular Ca2+ homeostasis, cytosolic [ADP] and deltaG of ATP hydrolysis underlies the regulation of cardiac cell function. As more experimental detail on the biochemistry and biophysics of these complex processes and their interactions accumulates, the intuitive interpretation of the new findings becomes increasingly impractical. For this reason we developed detailed biophysical model that couples Ca2+ signaling, cell electrophysiology and bioenergetics with the main interactions between phosphorylated species (ATP, ADP, AMP, PCr, Cr, P(i)) and Lewis cytosolic acids (Na+, K+, Mg2+, H+). The results indicate that the increase in free cytosolic Mg2+ (0.2-5 mM) systematically shortens the action potential duration. The analysis suggests that that under physiological conditions a pH decrease accompanied by a free Mg2+ increase tends to counteract an [ADP] increase due to PCr depletion. The model reproduces qualitatively a sequence of events that correlates well with the experimental data.
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