Polysaccharides from soybean residue fermented by Neurospora crassa alleviate DSS-induced gut barrier damage and microbiota disturbance in mice

FSRP can suppress inflammatory cytokines (IL-6 and IL-1β) and boost the anti-inflammatory cytokine IL-22 by manipulating specific bacteria ( e.g. Tenericutes , Clostridia , and Bacilli ), hence maintaining gut barrier integrity and alleviating colitis.