倍半萜
化学
立体化学
抑制性突触后电位
二维核磁共振波谱
炎症体
生物化学
生物
受体
神经科学
作者
Jing‐Jing Zhang,Y. Jun Xu,Rui Li,Yu Zhang,Chen‐Fang Yue,De‐Wen Bi,Bin Cheng,Xuewen Wu,Ruihan Zhang,Xing‐Jie Zhang,Xiaoli Li,Wei‐Lie Xiao
标识
DOI:10.1002/cbdv.202200135
摘要
Six new sesquiterpenoids, named as ainslides A-F (1-6), including one carotene-type sesquiterpene (1), one eudesmane (2), four guaianolides (3-6), together with eight known sesquiterpenoids (7-14), were purified from the whole plants of Ainsliaea pertyoides. The structures of these sesquiterpenoids were characterized based on spectroscopic methods including 1D and 2D NMR, HR-ESI-MS, UV, and IR spectra, together with ECD calculations and X-ray diffraction experiments. The anti-inflammatory activity of all the isolated compounds was screened and compounds 3 and 7-13 exhibited NLRP3-inflammasome inhibitory activity with IC50 values of 1.80-4.33 μM.
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