肌动蛋白
内科学
骨骼肌
内分泌学
下调和上调
mTORC1型
肌肉肥大
糖原合酶
PI3K/AKT/mTOR通路
蛋白激酶B
糖原
心肌细胞
化学
细胞生物学
生物
信号转导
医学
生物化学
基因
作者
Vera Lúcia de Menezes Lima,Álvaro Nóbrega de Melo Madureira,João Ricardhis Saturnino de Oliveira
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2022-10-01
卷期号:22 (18): 2419-2428
被引量:1
标识
DOI:10.2174/1389557522666220309161245
摘要
Interleukin-6 (IL-6) influences both inflammatory response and anti-inflammatory processes. This cytokine can be released by exercising skeletal muscle, which characterizes it as a myokine. Unlike what is observed in inflammation, IL-6 produced by skeletal muscle is not preceded by the release of other pro-inflammatory cytokines, but it seems to be dependent on the lactate produced during exercise, thus causing different effects from those seen in inflammatory state. After binding to its receptor, myokine IL-6 activates the PI3K-Akt pathway. One consequence of this upregulation is the potentiation of insulin signaling, which enhances insulin sensitivity. IL-6 increases GLUT-4 vesicle mobilization to the muscle cell periphery, increasing the glucose transport into the cell, and also glycogen synthesis. Muscle glycogen provides energy for ATP resynthesis, and regulates Ca2+ release by the sarcoplasmic reticulum, influencing muscle contraction, and, hence, muscle function by multiple pathways. Another implication for the upregulation of the PI3K-Akt pathway is the activation of mTORC1, which regulates mRNA translational efficiency by regulating translation machinery, and translational capacity by inducing ribosomal biogenesis. Thus, IL-6 may contribute to skeletal muscle hypertrophy and function by increasing contractile protein synthesis.
科研通智能强力驱动
Strongly Powered by AbleSci AI