Dietary Inflammatory Index score and prodromal Parkinson's disease incidence: The HELIAD study

医学 入射(几何) 内科学 帕金森病 队列 队列研究 人口 疾病 前瞻性队列研究 胃肠病学 物理 环境卫生 光学
作者
Vasileios Balomenos,Lamprini Bounou,Sokratis Charisis,María Stamelou,Eva Ntanasi,Kyriaki Georgiadi,Ioannis Mourtzinos,Katerina Tzima,Costas A. Anastasiou,Georgia Xiromerisiou,Maria I. Maraki,Mary Yannakoulia,Mary H. Kosmidis,Efthimios Dardiotis,Georgios M. Hadjigeorgiou,Paraskevi Sakka,Leonidas Stefanis,Nikolaos Scarmeas
出处
期刊:Journal of Nutritional Biochemistry [Elsevier]
卷期号:105: 108994-108994 被引量:7
标识
DOI:10.1016/j.jnutbio.2022.108994
摘要

The aim of the present study was to investigate the association of the inflammatory potential of diet with prodromal Parkinson's disease (pPD) probability and incidence among community-dwelling older individuals without clinical features of parkinsonism at baseline. The sample consisted of 1,030 participants 65 years old or older, drawn from a population-based cohort study of older adults in Greece (Hellenic Longitudinal Investigation of Aging and Diet - HELIAD). We calculated pPD probability, according to International Parkinson and Movement Disorder Society research criteria. Dietary Inflammatory Index (DII) was used to measure the dietary inflammatory potential, with higher index score reflecting a more pro-inflammatory diet. Associations of baseline DII with pPD probability cross-sectionally, and with possible/probable pPD incidence (pPD probability ≥30%) during the follow-up period, were examined via general linear models and generalized estimating equations, respectively. Cross-sectionally, one unit increase of DII score [DII (min, max) = -5.83, 6.01] was associated with 4.9% increased pPD probability [β=0.049, 95%CI (0.025-0.090), p<0.001]. Prospectively, 62 participants developed pPD during 3.1±0.9 (mean±SD) years of follow-up. One unit increase in DII was associated with 20.3% increased risk for developing pPD [RR=1.203, 95%CI (1.070-1.351), p=0.002]. Participants in the highest tertile of DII score were 2.6 times more likely to develop pPD [β=2.594, 95%CI (1.332-5.050), p=0.005], compared to those in the lowest tertile. More pro-inflammatory diet was related with higher pPD probability and pPD incidence (pPD probability ≥30%) in a community-dwelling older adult population. Further studies are needed to confirm these findings.
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