Palladium‐Catalyzed [4+2] Cycloaddition of Hydroxy‐Tethered Allylic Carbonates with Alkenes: Synthesis of Functionalized Tetrahydropyrans

Abstract A palladium‐catalyzed [4+2] cycloaddition of hydroxy‐tethered allyl carbonates with five types of electron‐deficient alkenes has been achieved, in which a type of new hydroxy‐tethered allyl carbonates acted as valuable precursors for the formation of 1,4‐C,O‐dipole allylpalladium intermediates. The reaction proceeded efficiently under mild reaction conditions to provide the corresponding tetrahydropyran derivatives in moderate to high yields with excellent diastereoselectivities. magnified image