植物化学
神经保护
化学
立体化学
传统医学
药理学
生物
生物化学
医学
作者
Yan Yuan,Zhuo-Fan Hu,Fengli Wang,Luo-Sheng Wan,Ying Gong,Jia-Chun Chen
标识
DOI:10.1080/10286020.2021.2017896
摘要
The phytochemical investigation of the methanol extract of Ixeris sonchifolia led to the isolation and identification of nine analogs, including one new guaiane-type sesquiterpenoid, named ixerinoid A (1). The structure of 1 was determined by extensive analysis of the 1 D and 2 D nuclear magnetic resonance spectroscopic data, as well as quantum chemical calculations. Additionally, all the isolates were tested for their neuroprotective activity using the oxygen-glucose deprivation/reperfusion-induced SH-SY5Y cell injury model. Compounds 3, 5, 6, 8, and 9 displayed remarkable protective effects at concentrations of 1, 5, and 10 μM, respectively.
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