卵清蛋白
敏化
乙酰甲胆碱
医学
内分泌学
内科学
细胞因子
发病机制
哮喘
免疫学
肥胖
炎症
肺
免疫系统
呼吸道疾病
作者
Mohammad Reza Aslani,Afshan Sharghi,Mohammad Hossein Boskabady,Hassan Ghobadi,Rana Keyhanmanesh,Mohammad Reza Alipour,Mahdi Ahmadi,Saeideh Saadat,Parya Naghizadeh
出处
期刊:Life Sciences
[Elsevier]
日期:2022-02-22
卷期号:296: 120425-120425
被引量:14
标识
DOI:10.1016/j.lfs.2022.120425
摘要
The association between asthma and obesity has been shown but its accurate mechanism is unknown. In the current study, we sought to investigate the gene expression levels of IL-17/TRAF6/MAPK/USP25 axis and pro-inflammatory cytokine level (IL-6, IL-1β, and TNF-α) in obese Ovalbumin (OVA)-sensitized female and male Wistar rats lung tissue. Animals in both males and females were divided into eight groups (four groups in each sex) based on diet and OVA-sensitization: normal diet, a normal diet with OVA-sensitization, high-fat diet (HFD), and OVA-sensitization with an HFD. In both sexes, obese OVA-sensitized rats, the methacholine concentration-response curve shifted to the left and EC50 methacholine decreased. Increased pro-inflammatory cytokines as well as elevated IL-17/TRAF6/MAPK axis genes and decreased USP25 gene expression were identified in obese OVA-sensitized groups. The results indicate that in obese OVA-sensitized rats, the IL-17 axis were involved in the pathogenesis of the disease and can be considered as a therapeutic target in subjects with obesity-related asthma.
科研通智能强力驱动
Strongly Powered by AbleSci AI