Integrative omics analysis identifies biomarkers of idiopathic pulmonary fibrosis

特发性肺纤维化 转录组 细胞外基质 生物 肺纤维化 纤维化 蛋白质组学 免疫系统 癌症研究 基因表达 细胞生物学 基因 免疫学 病理 医学 遗传学 内科学
作者
Peiyan Zheng,Shixue Sun,Jingxian Wang,Zhangkai J. Cheng,Kuan Cheok Lei,Mingshan Xue,Teng Zhang,Huimin Huang,Xiaohua Douglas Zhang,Baoqing Sun
出处
期刊:Cellular and Molecular Life Sciences [Springer Nature]
卷期号:79 (1) 被引量:12
标识
DOI:10.1007/s00018-021-04094-0
摘要

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by chronic progressive pulmonary fibrosis and a poor prognosis. Genetic studies, including transcriptomic and proteomics, have provided new insight into revealing mechanisms of IPF. Herein we provided a novel strategy to identify biomarkers by integrative analysis of transcriptomic and proteomic profiles of IPF patients. We examined the landscape of IPF patients' gene expression in the transcription and translation phases and investigated the expression and functions of two new potential biomarkers. Differentially expressed (DE) mRNAs were mainly enriched in pathways associated with immune system activities and inflammatory responses, while DE proteins are related to extracellular matrix production and wound repair. The upregulated genes in both phases are associated with wound repair and cell differentiation, while the downregulated genes in both phases are associated with reduced immune activities and the damage of the alveolar tissues. On this basis, we identified thirteen potential marker genes. Among them, we validated the expression changes of butyrophilin-like 9 (BTNL9) and plasmolipin (PLLP) and investigated their functional pathways in the IPF mechanism. Both genes are downregulated in the tissues of IPF patients and Bleomycin-induced mice, and co-expression analysis indicates that they have a protective effect by inhibiting extracellular matrix production and promoting wound repair in alveolar epithelial cells.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
愉快的楷瑞完成签到,获得积分10
2秒前
红李子发布了新的文献求助30
4秒前
倩倩完成签到,获得积分10
5秒前
SciGPT应助kk采纳,获得10
6秒前
昭昭完成签到,获得积分10
9秒前
星辰大海应助strings采纳,获得10
11秒前
12秒前
wshiyu完成签到 ,获得积分10
12秒前
星弟完成签到 ,获得积分10
14秒前
kk发布了新的文献求助10
15秒前
wyz完成签到 ,获得积分10
16秒前
充电宝应助冯丽雪采纳,获得10
16秒前
18秒前
zyy完成签到,获得积分10
18秒前
chcui完成签到,获得积分10
19秒前
苽峰完成签到,获得积分10
21秒前
zqingxia完成签到,获得积分10
21秒前
xh完成签到,获得积分10
22秒前
天天快乐应助美少女采纳,获得10
23秒前
23秒前
dont_love_study完成签到 ,获得积分10
26秒前
wenrui发布了新的文献求助10
26秒前
怕黑的立轩完成签到,获得积分10
26秒前
小孙完成签到,获得积分10
27秒前
红李子完成签到,获得积分10
27秒前
32秒前
32秒前
合适不愁完成签到,获得积分10
33秒前
33秒前
碗碗完成签到,获得积分10
33秒前
qiqi完成签到,获得积分10
34秒前
搞怪烨伟发布了新的文献求助10
35秒前
37秒前
美少女发布了新的文献求助10
38秒前
38秒前
39秒前
40秒前
wyj完成签到,获得积分10
40秒前
圆心角发布了新的文献求助10
42秒前
羊羊发布了新的文献求助30
42秒前
高分求助中
The Oxford Handbook of Social Cognition (Second Edition, 2024) 1050
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Handbook of Qualitative Cross-Cultural Research Methods 600
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3140266
求助须知:如何正确求助?哪些是违规求助? 2791039
关于积分的说明 7797809
捐赠科研通 2447561
什么是DOI,文献DOI怎么找? 1301942
科研通“疑难数据库(出版商)”最低求助积分说明 626345
版权声明 601194