Copper‐catalyzed direct synthesis of arylated 8‐aminoquinolines through chelation assistance

Abstract Copper‐catalyzed N , N ‐diarylation and N ‐arylation of unprotected 8‐aminoquinoline derivatives with aryl halides have been described for the formation of C–N bonds. This protocol provides an efficient approach to synthesize a series of arylamines with tolerance to a wide range of functional groups for formation of key intermediates in many natural products.