Plant-derived bioactive compounds in colon cancer treatment: An updated review

迷迭香酸 山奈酚 结直肠癌 药理学 化学 木犀草素 癌症 保健品 齐墩果酸 生物化学 传统医学 抗氧化剂 槲皮素 医学 生物 替代医学 病理 遗传学
作者
Akanksha Esmeeta,Subhamay Adhikary,V. Dharshnaa,P. Swarnamughi,Z. Ummul Maqsummiya,Antara Banerjee,Surajit Pathak,Asim K. Duttaroy
出处
期刊:Biomedicine & Pharmacotherapy [Elsevier BV]
卷期号:153: 113384-113384 被引量:145
标识
DOI:10.1016/j.biopha.2022.113384
摘要

Colon cancer is the third most predominant cancer caused by genetic, environmental and nutritional factors. Plant-based compounds are very well known to regress colon cancer in many ways, like delaying tumor growth, managing chemotherapy and radiation therapy side-effects, and working at the molecular levels. Medicinal plants contain many bioactive phytochemicals such as flavonoids, polyphenol compounds, caffeic acid, catechins, saponins, polysaccharides, triterpenoids, alkaloids, glycosides, phenols, quercetin, luteolin, kaempferol and luteolin glycosides, carnosic acid, oleanolic acid, rosmarinic acid, emodin, and eugenol and anthricin. These bioactive compounds can reduce tumor cell proliferation via several mechanisms, such as blocking cell cycle checkpoints and promoting apoptosis through activating initiator and executioner caspase. Traditional medicines have been used globally to treat cancers because of their anti-cancer effects, antioxidant properties, anti-inflammatory properties, anti-mutagenic effects, and anti-angiogenic effects. In addition, these medicines effectively suppress early and intermediate stages of carcinogenesis when administered in their active and pure form. However, traditional medicine is not very popular due to some critical challenges. These include poor solubility and absorption of these compounds, intellectual property-related issues, involvement of drug synergism, absence of drug-likeness, and unsure protocols for their extraction from the plant source. Using bioactive compounds in colon cancer has equal advantages and limitations. This review highlights the benefits and challenges of using bioactive compounds derived from plants for colon cancer. We have also discussed using these compounds to target cancer stem cell self-renewal, its effects on cancer cell metabolism, safety parameters, easy modulation, and their bioavailability.
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