已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Plant-derived bioactive compounds in colon cancer treatment: An updated review

迷迭香酸 山奈酚 结直肠癌 药理学 化学 木犀草素 癌症 保健品 齐墩果酸 生物化学 传统医学 抗氧化剂 槲皮素 医学 替代医学 病理 内科学
作者
Akanksha Esmeeta,Subhamay Adhikary,V. Dharshnaa,P. Swarnamughi,Z. Ummul Maqsummiya,Antara Banerjee,Surajit Pathak,Asim K. Duttaroy
出处
期刊:Biomedicine & Pharmacotherapy [Elsevier]
卷期号:153: 113384-113384 被引量:125
标识
DOI:10.1016/j.biopha.2022.113384
摘要

Colon cancer is the third most predominant cancer caused by genetic, environmental and nutritional factors. Plant-based compounds are very well known to regress colon cancer in many ways, like delaying tumor growth, managing chemotherapy and radiation therapy side-effects, and working at the molecular levels. Medicinal plants contain many bioactive phytochemicals such as flavonoids, polyphenol compounds, caffeic acid, catechins, saponins, polysaccharides, triterpenoids, alkaloids, glycosides, phenols, quercetin, luteolin, kaempferol and luteolin glycosides, carnosic acid, oleanolic acid, rosmarinic acid, emodin, and eugenol and anthricin. These bioactive compounds can reduce tumor cell proliferation via several mechanisms, such as blocking cell cycle checkpoints and promoting apoptosis through activating initiator and executioner caspase. Traditional medicines have been used globally to treat cancers because of their anti-cancer effects, antioxidant properties, anti-inflammatory properties, anti-mutagenic effects, and anti-angiogenic effects. In addition, these medicines effectively suppress early and intermediate stages of carcinogenesis when administered in their active and pure form. However, traditional medicine is not very popular due to some critical challenges. These include poor solubility and absorption of these compounds, intellectual property-related issues, involvement of drug synergism, absence of drug-likeness, and unsure protocols for their extraction from the plant source. Using bioactive compounds in colon cancer has equal advantages and limitations. This review highlights the benefits and challenges of using bioactive compounds derived from plants for colon cancer. We have also discussed using these compounds to target cancer stem cell self-renewal, its effects on cancer cell metabolism, safety parameters, easy modulation, and their bioavailability.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
追寻的山晴应助大观天下采纳,获得50
1秒前
nil发布了新的文献求助10
2秒前
3秒前
FashionBoy应助堀江真夏采纳,获得10
7秒前
Ava应助konekone采纳,获得10
7秒前
aaaa完成签到,获得积分10
11秒前
科研通AI2S应助唐唐采纳,获得10
12秒前
13秒前
完美世界应助Hanni采纳,获得10
14秒前
温暖冬日发布了新的文献求助30
16秒前
Pig-prodigy完成签到,获得积分10
17秒前
oceanao应助AnjeXi采纳,获得10
22秒前
23秒前
实验大牛完成签到,获得积分10
26秒前
29秒前
30秒前
ZhY发布了新的文献求助10
30秒前
勤恳的画笔完成签到 ,获得积分10
31秒前
打打应助漂亮幻莲采纳,获得10
31秒前
堀江真夏发布了新的文献求助10
32秒前
所所应助123采纳,获得10
34秒前
123完成签到 ,获得积分10
34秒前
tsuki完成签到 ,获得积分10
35秒前
ZLY完成签到 ,获得积分10
36秒前
友好的储发布了新的文献求助10
37秒前
温暖冬日完成签到,获得积分10
38秒前
38秒前
慕青应助黙宇循光采纳,获得10
40秒前
41秒前
慕青应助tt采纳,获得10
42秒前
43秒前
漂亮幻莲发布了新的文献求助10
43秒前
44秒前
123发布了新的文献求助10
47秒前
小二郎应助思洁WAIT采纳,获得10
47秒前
50秒前
可耐的妙海关注了科研通微信公众号
51秒前
ZhY完成签到,获得积分10
53秒前
54秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3161864
求助须知:如何正确求助?哪些是违规求助? 2813088
关于积分的说明 7898593
捐赠科研通 2472111
什么是DOI,文献DOI怎么找? 1316332
科研通“疑难数据库(出版商)”最低求助积分说明 631278
版权声明 602129