单线态氧
光动力疗法
渗透(战争)
体内
纳米反应器
纳米颗粒
氧气
生物物理学
金属
肿瘤微环境
活性氧
水溶液中的金属离子
光敏剂
化学
材料科学
纳米技术
光化学
生物化学
癌症研究
肿瘤细胞
有机化学
生物
生物技术
工程类
运筹学
作者
Yu-e Wang,Junqiu Zhai,Yuxiu Zheng,Jiali Pan,Xiaojia Liu,Yan Ma,Shixia Guan
出处
期刊:Nanoscale
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:14 (31): 11388-11406
被引量:8
摘要
The generation of singlet oxygen (1O2) using photodynamic therapy (PDT) is limited by the hypoxia of the tumor microenvironment and the depth of external light penetration because it depends on the precise cooperation between the photosensitizers, oxygen, and light. Herein, we report a self-sufficient 1O2 nanoreactor with enhanced penetration into deep tumors for cancer therapy. Linoleic acid hydroperoxide (LAHP) is coordinated with transition metal ions (Cu2+/Fe3+) to prepare linoleic acid hydroperoxide metal complex nanoparticles (LAHP-M NPs). iRGD combined with R7 decoration endows the nanoparticles with tumor targeting and penetration ability. We show that the polypeptide carries the nanoparticles into deep tumors, and thereafter the nanoparticles are disassembled into LAHP and catalytical metal ions to produce 1O2 based on the Russell mechanism under the stimulation of acidic pH. The elevated ROS induces necrotic cell death in vitro and in vivo, and further causes immunogenic cell death (ICD). This study demonstrates the effectiveness of exploiting biochemical reactions as a spatial-temporal strategy to overcome the current limitations of photodynamic therapy.
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