Nanoscintillator-Based X-Ray-Induced Photodynamic Therapy

Photodynamic therapy (PDT) is an emerging treatment option for cancer. In PDT, photosensitizers are delivered to tumors and stimulated by light to generate reactive oxygen species (ROS)-most importantly singlet oxygen (1O2)-to damage tumor cells or induce tissue ischemia. PDT is associated with a low level of systemic toxicity because photosensitizers are usually pharmaceutically inactive in the dark and photoirradiation is applied only to tumor areas in the procedure. Additionally, PDT can be applied repeatedly without cumulative toxicity or incurring resistance, and may stimulate systemic anti-tumor immunity. However, PDT's clinical use has been restricted due to the limited penetration of visible light through tissues. X-rays possess superior tissue penetration capability and are exploited in X-ray-induced photodynamic therapy to overcome this limitation. Herein we have demonstrated this principle with a novel LiGa5O8:Cr (LGO:Cr)-based nanoscintillator which emits near-infrared X-ray luminescence to both guide external beam therapy and induce PDT with the photosensitizer (2,3-naphthalocyanine) encapsulated in a mesoporous silica shell of the nanoscintillator.