异黄酮素
槐花
烟草花叶病毒
化学
阳性对照
IC50型
传统医学
胞苷
立体化学
黄酮类
体外
病毒
生物
生物化学
色谱法
受体
医学
中医药
病毒学
替代医学
烟碱激动剂
病理
作者
Daojun Chen,Shuang Yuan,Peng Zhang,Qiao An,Ji Zou,Chun-Mao Yuan,Lihua Zhao,Zhan-Xing Hu,Xiao-Jiang Hao
标识
DOI:10.1080/10286020.2022.2077200
摘要
Two new isoflavones (1 and 2), as well as eight known ones were isolated from the roots of Sophora tonkinensis Gagnep. Compound 1 represents an unprecedented polymerization pattern constructed by isoflavone and cytisine. Their structures were elucidated by comprehensive spectroscopic data analysis, combined with ECD calculations. Compound 1 displayed significant anti-tobacco mosaic virus (TMV) activity compared with the positive control ningnanmycin. Moreover, compound 6 exhibited potent α-glucosidase inhibitory activity with IC50 value of 47.4 mg/L.
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