Metabolically obese phenotype and its dynamic change are associated with increased carotid intima-media thickness: Results from a cohort study

内膜中层厚度 医学 内科学 混淆 队列 前瞻性队列研究 肥胖 逻辑回归 队列研究 内分泌学 颈动脉
作者
Liping Yang,Xue Li,Li Wang,Shan Xu,Yanmei Lou,Fulan Hu
出处
期刊:Nutrition Metabolism and Cardiovascular Diseases [Elsevier BV]
卷期号:32 (9): 2238-2245 被引量:4
标识
DOI:10.1016/j.numecd.2022.06.012
摘要

To examine associations between metabolically obese phenotypes or their changes and increased carotid intima-media thickness (CIMT).This prospective cohort included 13,681 Chinese adults aged 20-80 years who completed follow-up health examination with carotid ultrasound and were divided according to metabolic and weight status: metabolically healthy and normal weight (MHNW); metabolically obese but normal weight (MONW); metabolically healthy but obese (MHO); metabolically abnormal and obese (MAO). Cox and logistic regression were used to evaluate the associations of the phenotypes or their changes with increased CIMT. During a mean follow-up of 33 months, 1927 participants developed increased CIMT. After adjusting for age, sex and potential biochemical confounders, MAO was significantly associated with increased CIMT (HR 1.22, 95% CI [1.07, 1.4]); the association remained significant in those 40 years or older. Compared with stable MHNW, increased CIMT risk was higher for stable MAO (OR 1.35 [1.16, 1.57]), transitional MAO from MONW (OR 1.44 [1.04, 1.97]), and transitional MHO from MHNW (OR 1.59 [1.10, 2.26]) in demographic adjusted models; only stable MAO remained significant in the multivariate adjusted model (OR 1.23 [1.05, 1.45]).MAO significantly elevated the risk of increased CIMT. Stable MAO and obese transitions also promoted CIMT progression.
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