Studies on the Vilsmeier-Haack Reaction. III. Synthesis of Cytidine Diphosphate Choline

Cytidine diphosphate choline (CDP-choline), one of the nucleotide coenzymes having pyrophosphate linkages, was synthesized in a fairly good yield by the direct condensation of cytidine-5'monophosphate (5'-CMP) and choline phosphate (P-choline) by means of thionyl chloride combined with dimethylformamide (Vilsmeier-Haack reagent).