生物利用度
镉
砷
化学
环境化学
基质(化学分析)
排泄
毒性
土壤水分
锰
原子吸收光谱法
吸收(声学)
色谱法
生物化学
药理学
生物
材料科学
物理
有机化学
复合材料
量子力学
生态学
作者
Cameron J. Ollson,Euan Smith,Paul Herde,Albert L. Juhasz
标识
DOI:10.1016/j.scitotenv.2017.04.036
摘要
In this study, the influence of sample matrix on the relative bioavailability of arsenic (As), cadmium (Cd) and lead (Pb) was assessed following exposure of C57BL/6 mice to spiked aged (12 years) soils. AIN93G mouse chow was amended with individual and tertiary As, Cd and Pb soil combinations which were administered to mice over a 9 day exposure period. Contaminant relative bioavailability was calculated by comparing As urinary excretion and Cd-kidney/Pb-liver accumulation to corresponding values for compounds used to derive the respective toxicity reference value. Strong linear dose-responses were observed for mice exposed to AIN93G mouse chow augmented with individually spiked soil with As, Cd and Pb. When mice were exposed to co-contaminants, As relative bioavailability (RBA) decreased similar to results from previous co-contaminant salt experiments presumably due to the influence of Cd on phosphate transport proteins, which are utilized for As absorption. However, a decrease in Cd-kidney and Pb-liver accumulation was also observed following co-co-exposure. It was postulated that this resulted from interactions with other (essential) metals (e.g. iron, aluminium, manganese, magnesium) within the soil matrix and their influence on absorption via divalent metal transporters.
科研通智能强力驱动
Strongly Powered by AbleSci AI