Long non-coding RNAs regulating multiple proliferative pathways in cancer cell

乙二醇 热空气 马拉特1 抑制器 生物 细胞生长 癌症研究 长非编码RNA 背景(考古学) 癌症 表观遗传学 核糖核酸 细胞生物学 计算生物学 遗传学 基因 古生物学
作者
Marco De Martino,Francesco Esposito,Pierlorenzo Pallante
出处
期刊:Translational cancer research [AME Publishing Company]
卷期号:10 (6): 3140-3157 被引量:9
标识
DOI:10.21037/tcr-21-230
摘要

Long non-coding RNAs (lncRNAs) belong to an extremely heterogeneous class of non-coding RNAs with a length ranging from 200 to 100,000 bp. They modulate a series of cellular pathways in both physiological and pathological context. It is no coincidence that they are expressed in an aberrant way in pathologies such as cancer, so as to deserve to be subclassified as oncogenes or tumor suppressors. These molecules are also involved in the regulation of cancer cell proliferation. Several lncRNAs are able to modulate cell growth both positively and negatively, and in this review we have focused on a small group of them, characterized by the simultaneous action on different pathways regulating cell proliferation. They have been considered in the light of their behavior in three different subtypes of proliferative pathways that we can define as (I) tumor suppressor, (II) oncogenic and (III) transcriptionally-driven. More specifically, we have characterized some lncRNAs considered oncogenes (such as H19, linc-ROR, MALAT1, HULC, HOTAIR and ANRIL), tumor suppressors (such as MEG3 and lincRNA-p21), and both oncogenes/tumor suppressors (UCA1 and TUG1) in a little more detail. As can be understood from the review, the interactions between lncRNAs and their molecular targets, only in the context of controlling cell proliferation, give rise to an intricate molecular network, the understanding of which, in the future, will certainly be of help for the treatment of molecular diseases such as cancer.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
zjy完成签到,获得积分10
刚刚
yinyin发布了新的文献求助10
1秒前
伍佰完成签到,获得积分10
2秒前
量子星尘发布了新的文献求助10
2秒前
雪地太阳完成签到 ,获得积分10
2秒前
dididi完成签到,获得积分10
2秒前
agui完成签到 ,获得积分10
2秒前
2秒前
koly完成签到 ,获得积分10
2秒前
Meowly完成签到,获得积分10
2秒前
3秒前
欢呼凝冬完成签到 ,获得积分20
5秒前
Ming完成签到,获得积分10
5秒前
A_Caterpillar完成签到,获得积分10
6秒前
张牧之完成签到 ,获得积分10
6秒前
7秒前
小甜桶完成签到,获得积分10
7秒前
7秒前
深情安青应助玄笺采纳,获得10
8秒前
yjm完成签到,获得积分10
8秒前
温暖的皮皮虾完成签到,获得积分10
8秒前
bkagyin应助MY采纳,获得10
8秒前
橘子完成签到,获得积分10
8秒前
cxt完成签到,获得积分10
9秒前
有魅力棉花糖完成签到,获得积分10
9秒前
麻雀完成签到,获得积分10
9秒前
NexusExplorer应助Echo采纳,获得10
9秒前
10秒前
曾经听云完成签到,获得积分10
11秒前
11秒前
魔幻若血完成签到,获得积分10
11秒前
SeliqAq发布了新的文献求助10
11秒前
CHAosLoopy应助蒋开耀采纳,获得10
12秒前
12秒前
hhhhhh应助洁净的易巧采纳,获得10
12秒前
李爱国应助终梦采纳,获得10
12秒前
yydssss完成签到,获得积分10
13秒前
大胖小子完成签到,获得积分10
14秒前
15秒前
CodeCraft应助博慧采纳,获得10
16秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 2390
A new approach to the extrapolation of accelerated life test data 1000
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4009167
求助须知:如何正确求助?哪些是违规求助? 3549013
关于积分的说明 11300491
捐赠科研通 3283494
什么是DOI,文献DOI怎么找? 1810370
邀请新用户注册赠送积分活动 886146
科研通“疑难数据库(出版商)”最低求助积分说明 811259