Sleep: Critical for Brain Health

Your Patient's Brain| November 2021 Sleep: Critical for Brain Health Lei Gao, MBBS; Lei Gao, MBBS Search for other works by this author on: This Site PubMed Google Scholar Daniel J. Cole, MD, FASA; Daniel J. Cole, MD, FASA Search for other works by this author on: This Site PubMed Google Scholar Oluwaseun Akeju, MD, MMSc; Oluwaseun Akeju, MD, MMSc Search for other works by this author on: This Site PubMed Google Scholar Susana Vacas, MD, PhD Susana Vacas, MD, PhD Search for other works by this author on: This Site PubMed Google Scholar ASA Monitor November 2021, Vol. 85, 16–17. https://doi.org/10.1097/01.ASM.0000798500.18032.d9 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Search Site Citation Lei Gao, Daniel J. Cole, Oluwaseun Akeju, Susana Vacas; Sleep: Critical for Brain Health. ASA Monitor 2021; 85:16–17 doi: https://doi.org/10.1097/01.ASM.0000798500.18032.d9 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll PublicationsASA Monitor Search Advanced Search Topics: brain, sleep Sleep, an evolutionarily conserved state of decreased arousal, is fundamental for healthy cardiovascular, immune, and cognitive function (Curr Opin Neurobiol 2017;44:178-85). We are typically active during the day and sleep during the night. This is because the homeostatic sleep drive and circadian rhythm interact to regulate sleep (J Biol Rhythms 1999;14:557-68). The homeostatic sleep drive strengthens with every waking hour and may be regulated by increasing adenosine concentrations in the brain. This perhaps explains why caffeine, an adenosine receptor antagonist, promotes wakefulness. Circadian rhythms are internally driven cycles of biological processes that typically adhere to approximate 24-hour cycles. The suprachiasmatic nucleus controls the production of melatonin to regulate our sleep-wake cycle. Unfortunately, sleep and circadian disturbances are highly prevalent in the general population (Int J Epidemiol 2011;40:1431-7). Sleep disturbance is a hallmark feature of the perioperative period (Anesthesiology 2016;125:979-91). The effect of... You do not currently have access to this content.