Structural and functional cerebellar alterations in Parkinson's disease with postural instability and gait disorders

Brain structures other than basal ganglia are likely to be involved in the pathophysiological process of Parkinson's disease (PD). The role of cerebellum in PD has been explored during motor tasks involving the hand, while few studies investigated its activity during gait-simulating tasks and dual-task situations. This study aimed at assessing structural and task-based functional cerebellar alterations in PD patients with postural instability and gait disorders (PD-PIGD).