Pd‐Catalyzed Amidation of Silyl Enol Ethers With CO and Azides via an Isocyanate Intermediate

Abstract An efficient Pd‐catalyzed amidation of silyl enol ethers to produce β‐ketoamides has been developed using carbon monoxide and sulfonyl azides. The tandem reaction provides a simple and straightforward approach for the synthesis of β‐ketoamides under mild conditions without any additive. The mechanistic studies indicate that the reaction undergoes via an in situ generated isocyanate intermediate.