349P The amount of cancer stem cells and the sensitivity to anticancer drugs in glioblastoma primary cell culture

It is assumed that aggressiveness and therapy resistance of glioblastoma multiforme (GBM) is determined by its high heterogeneity and presence of cancer stem cells (CSC). The primary glioblastoma cell lines (pGBM lines) could better than the cultured cell lines reflect the tumor heterogeneity and, thus, provide the additional opportunities for personalized medicine. In our study, we compared the response of the pGBM lines and cell glioblastoma lines to chemotherapy drugs with the CSC content in cell cultures.