化学
催化作用
光催化
表面改性
过渡金属
组合化学
路易斯酸
有机合成
有机化学
光化学
光催化
物理化学
作者
Ziqi Ye,Yu‐Mei Lin,Lei Gong
标识
DOI:10.1002/ejoc.202101036
摘要
Abstract Catalytic C(sp 3 )−H functionalization can convert abundant feedstock hydrocarbons into value‐added products in an atom‐ and step‐economic manner and is a powerful tool in organic synthesis. However, the intrinsic chemical inertness of ubiquitous aliphatic C−H bonds of alkanes and cycloalkanes makes their direct and selective functionalization extremely challenging. Recently, some elegant strategies have been developed to solve the problems based on the merger of photocatalyzed hydrogen atom transfer (HAT) with transition metal catalysis. Light‐induced HAT processes are employed to initiate the alkyl radical generation, which is synergistic with metal catalysis involving for example nickel, copper, cobalt, cerium, chromium, or manganese. The different metal catalysts provide redox adjustment, Lewis acid activation or other functionalities and tune the reactivity and selectivity of the radical‐mediated sequences, allowing the development of diverse chemo‐, site‐, and/or stereoselective synthetic reactions. In this minireview, we offer a brief summary of the recent advances in dual photo‐induced HAT and transition metal catalysis for C−H functionalization of alkanes and cycloalkanes. We expect that these methodologies will stimulate the applications in catalysis, pharmaceuticals, and other related fields.
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