A highly active Cp*Ir complex with an anionic N,N-donor chelate ligand catalyzes the robust regeneration of NADH under physiological conditions

Anionic N,N-donor ligand chelate iridium complex [Cp*Ir(pba)Cl] 3 was developed, and exhibited the highest activity for NADH regeneration so far and stable chemoenzymatical coordinate catalytic performance for acetophenone enantioselective hydrogenation.