化学
羟醛反应
催化作用
对映选择合成
有机化学
药物化学
羟醛缩合
作者
Akira Yanagisawa,Aiko Kawada
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2021-04-12
卷期号:32 (12): 1246-1252
摘要
A catalytic enantioselective aldol reaction of alkenyl esters with isatins was achieved using a DM-BINAP·AgOTf complex as the chiral precatalyst and N,N-diisopropylethylamine as the base precatalyst in the presence of methanol or 2,2,2-trifluoroethanol. Optically active 3-alkylated 3-hydroxy-2-oxindoles having up to 98% ee were diastereoselectively obtained in moderate to high yields not only from cyclic alkenyl esters but also from acyclic ones through the in situ generated chiral silver enolates.
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