Immune profiling demonstrates a common immune signature of delayed acquired immunodeficiency in patients with various etiologies of severe injury

免疫系统 医学 免疫学 病因学 败血症 免疫失调 获得性免疫系统 先天免疫系统 内科学
作者
Fabienne Venet,Julien Textoris,Sophie Blein,Mary Luz Arcila,Maxime Bodinier,Bertrand Canard,Pierre Cortez,Boris Meunier,Lionel Tan,Craig Tipple,Laurence Quéméneur,Frédéric Reynier,Philippe Leissner,Christophe Védrine,Y. Bouffard,Benjamin Delwarde,Olivier Martin,Thibaut Girardot,Cyrille Truc,Andrew D. Griffiths,Virginie Moucadel,Alexandre Pachot,Guillaume Monneret,Thomas Rimmelé
出处
期刊:Cold Spring Harbor Laboratory - medRxiv 被引量:3
标识
DOI:10.1101/2021.03.12.21253466
摘要

Abstract Background and Research Question The host response plays a central role in the pathophysiology of sepsis and severe injuries. So far, no study has comprehensively described the overtime changes of the injury-induced immune profile in a large cohort of critically ill patients with different etiologies. Study Design and Methods 353 septic, trauma and surgical patients and 175 healthy volunteers were prospectively included in the REAnimation Low Immune Status Marker (REALISM) study. Extensive immune profiling was performed by assessing cellular phenotypes and functions, protein and mRNA levels at days 1-2, 3-4 and 5-7 after inclusion using a panel of 30 standardized immune markers. Results Using REALISM immunomonitoring panel, no specificity in the immune profile was observed between septic, trauma and surgical patients. This common injury-induced immune response was characterized by an initial adaptive (i.e. physiologic) response engaging all constituents of the immune system (pro- and anti-inflammatory cytokine release, innate and adaptive immune responses) but not associated with increased risk of secondary infections. In contrary, the persistence in a subgroup of patients of profound immune alterations at the end of the first week after admission was associated with increased risk of secondary infections independently of exposure to invasive devices. The combined monitoring of markers of pro/anti-inflammatory, innate and adaptive immune responses allowed a better enrichment of patients with risk of secondary infections in the selected population. Interpretation These results illustrate the delayed development of a common maladaptive injury-acquired immunodeficiency in a subgroup of severely injured patients independently of initial etiologies. Critically ill patients’ immune status could be captured through the combined monitoring a common panel of complementary markers of pro/anti-inflammatory, innate and adaptive immune responses. Such immune monitoring panel will help clinicians to identify critically ill patients who could benefit from tailored immunoadjuvant therapies. Clinical Trial Registration clinicaltrials.gov: NCT02638779 Summary conflict of interest statements JT, SB, VM and AP are employees of bioMérieux SA, an in vitro diagnostic company. FV, TR, YB, BD, OM, TG, CT and GM are employees of Hospices Civils de Lyon. JT, TR, SB, VM, AP, FV and GM work in a joint research unit, co funded by the Hospices Civils de Lyon and bioMérieux. JT, AP, GM and FV are co-inventors in patent applications covering the following markers: CX3CR1, CD127, IL10 and S100A9. LKT and CT are employees of and hold stock and shares in GlaxoSmithKline. LQU is an employee of Sanofi Pasteur. PC was employee of Sanofi, Inc. and declares no other competing interests. Funding information This study received funding from the Agence Nationale de la Recherche through a grant awarded to BIOASTER (Grant number #ANR-10-AIRT-03) and from bioMérieux, Sanofi and GSK.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
victory_liu完成签到,获得积分10
2秒前
taoxz521完成签到 ,获得积分10
12秒前
陈米花完成签到,获得积分10
15秒前
yyjl31完成签到,获得积分10
15秒前
Simon_chat完成签到,获得积分10
15秒前
Aprilzhou完成签到,获得积分10
16秒前
吐司炸弹完成签到,获得积分10
17秒前
mayfly完成签到,获得积分10
17秒前
奈思完成签到 ,获得积分10
18秒前
非洲大象完成签到,获得积分10
20秒前
carrot完成签到 ,获得积分10
35秒前
宸浅完成签到 ,获得积分10
38秒前
快乐的蓝完成签到 ,获得积分10
43秒前
JF123_完成签到 ,获得积分20
50秒前
courage完成签到,获得积分10
50秒前
ussiMi完成签到 ,获得积分10
52秒前
沿途东行完成签到 ,获得积分10
53秒前
手帕很忙完成签到,获得积分10
1分钟前
铜豌豆完成签到 ,获得积分10
1分钟前
652183758完成签到 ,获得积分10
1分钟前
gmc完成签到 ,获得积分10
1分钟前
xianyaoz完成签到 ,获得积分10
1分钟前
GIPCY完成签到 ,获得积分10
1分钟前
洁净的盼易完成签到 ,获得积分10
1分钟前
芝诺的乌龟完成签到 ,获得积分0
1分钟前
NN完成签到,获得积分10
1分钟前
Richardisme完成签到 ,获得积分10
1分钟前
丹青完成签到 ,获得积分10
1分钟前
魔幻的慕梅完成签到 ,获得积分10
1分钟前
慧慧子完成签到 ,获得积分10
1分钟前
croissante完成签到 ,获得积分10
1分钟前
现代的含雁完成签到 ,获得积分10
1分钟前
wpybird完成签到,获得积分10
1分钟前
Jemezs完成签到,获得积分10
1分钟前
马登完成签到,获得积分10
1分钟前
梅啦啦完成签到 ,获得积分10
1分钟前
1分钟前
wyt发布了新的文献求助10
1分钟前
2分钟前
北笙完成签到 ,获得积分10
2分钟前
高分求助中
Sustainability in Tides Chemistry 1500
Handbook of the Mammals of the World – Volume 3: Primates 805
拟南芥模式识别受体参与调控抗病蛋白介导的ETI免疫反应的机制研究 550
Gerard de Lairesse : an artist between stage and studio 500
Digging and Dealing in Eighteenth-Century Rome 500
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
Manual of Sewer Condition Classification 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3068255
求助须知:如何正确求助?哪些是违规求助? 2722176
关于积分的说明 7476072
捐赠科研通 2369142
什么是DOI,文献DOI怎么找? 1256228
科研通“疑难数据库(出版商)”最低求助积分说明 609518
版权声明 596835