Real‐life experience of a lidocaine/tetracaine self‐occluding topical anesthetic for dermatological procedures

医学 表面麻醉剂 耐受性 丁卡因 利多卡因 麻醉 不利影响 可视模拟标度 临床终点 外科 麻醉剂 随机对照试验 内科学
作者
Juan ­Jimenez‐Cauhe,P. Boixeda,Paloma Cornejo,Sergio Fernandez,María Alejandra Vitale,Carlos Serra
出处
期刊:Journal of Cosmetic Dermatology [Wiley]
卷期号:21 (7): 2939-2944 被引量:1
标识
DOI:10.1111/jocd.14583
摘要

Abstract Background Pliaglis ® is a self‐occluding topical anesthetic containing a eutectic mixture of 7% lidocaine and 7% tetracaine, with proven efficacy and safety in several trials. Aims To evaluate the effectiveness and safety of Pliaglis ® for different dermatological procedures in real‐life clinical practice. Methods This retrospective, multicenter study included 35 patients treated with Pliaglis ® prior to five dermatological procedures (pulsed dyed laser, picosecond laser, non‐ablative fractional laser, radiofrequency microneedling, and photodynamic therapy). The primary endpoint was to assess the pain during the procedure with a visual analogue score (VAS) from 0 (no pain) to 10 (most severe pain). Secondary endpoints were the global effectiveness and tolerability (from 0 = very low to 10 = excellent), and the adverse events (AEs) after Pliaglis ® removal, classified according to intensity (1–3). Results The median and mean pain VAS reported by patients was 2 (range 0–9) and 2.9 (±2.3), respectively. More than 65% of the patients had a VAS score ≤3. The effectiveness reported by investigators was “very good” (median 8 [range 2–10], mean 7.5 [±1.9]), which was strongly correlated with the pain VAS reported by patients (Spearman coefficient = ‐ 0.9; p < 0.001). Forty‐five percent of patients reported AEs and they were transient and mostly mild, with a mean intensity score of 1.5 (range 1–3). Tolerability of Pliaglis ® was reported by investigators as “excellent” (median 10 [range 1–10], mean 9 [±1.8]). Conclusions Pliaglis ® is an effective topical anesthetic for several dermatological procedures, with an excellent safety and tolerability profile.
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