分割
脊椎动物
生物
节肢动物
昆虫
基因
胚胎
进化生物学
机制(生物学)
解剖
计算生物学
细胞生物学
遗传学
人工智能
计算机科学
植物
生态学
物理
量子力学
作者
Andrés F. Sarrazin,Andrew Peel,Michalis Averof
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2012-04-20
卷期号:336 (6079): 338-341
被引量:197
标识
DOI:10.1126/science.1218256
摘要
Vertebrate segmentation relies on a mechanism characterized by oscillating gene expression. Whether this mechanism is used by other segmented animals has been controversial. Rigorous proof of cyclic expression during arthropod segmentation has been lacking. We find that the segmentation gene odd-skipped (Tc-odd) oscillates with a two-segment periodicity in the beetle Tribolium castaneum. By bisecting embryos and culturing the two halves over different time intervals, we demonstrate that Tc-odd cycles with a period of about 95 minutes at 30°C. Using live imaging and cell tracking in green fluorescent protein-expressing embryos, we can exclude that cell movements explain this dynamic expression. Our results show that molecular oscillators represent a common feature of segmentation in divergent animals and help reconcile the contrasting paradigms of insect and vertebrate segmentation.
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