Biomarkers of pesticide exposure and diabetes in the 1999–2004 National Health and Nutrition Examination Survey

七氯 全国健康与营养检查调查 优势比 杀虫剂 糖尿病 逻辑回归 医学 内科学 环境卫生 内分泌学 人口 生物 有机氯农药 农学
作者
Charles J. Everett,Eric M. Matheson
出处
期刊:Environment International [Elsevier BV]
卷期号:36 (4): 398-401 被引量:93
标识
DOI:10.1016/j.envint.2010.02.010
摘要

The associations of 8 pesticides and pesticide metabolites with total diabetes (diagnosed and undiagnosed) and pre-diabetes (glycohemoglobin 5.7–6.4%) were evaluated using the National Health and Nutrition Examination Survey (NHANES), 1999–2004. Six of the pesticides were found to be associated with total diabetes in separate adjusted logistic regressions. These pesticides and pesticide metabolites were beta-hexachlorocyclohexane, p,p′-DDE, p,p′-DDT, oxychlordane, trans-nonachlor, and heptachlor epoxide. When the number of compounds elevated was tested, 4 or more, of the 6, elevated had an odds ratio of 4.99 (95% CI 1.97–12.61) compared to none elevated. When the 6 compounds were tested together in a single combined adjusted logistic regression only oxychlordane, a metabolite of chlordane, and heptachlor epoxide, a metabolite of heptachlor, were significantly associated with total diabetes. In the combined adjusted logistic regression, oxychlordane ≥ 14.5 ng/g lipid adjusted had an odds ratios of 1.90 (95% CI 1.09–3.32) compared to oxychlordane < 14.5 ng/g lipid adjusted, and heptachlor epoxide ≥ 14.6 ng/g lipid adjusted had an odds ratio of 1.70 (95% CI 1.16–2.49) compared to heptachlor epoxide < 14.6 ng/g lipid adjusted. Heptachlor epoxide and p,p′-DDT were significantly associated with pre-diabetes in separate adjusted logistic regressions. When these 2 compounds were tested together only heptachlor epoxide remained significantly associated with pre-diabetes. The evidence supporting the relationship between pesticides and pesticide metabolites, with diabetes, was strongest for heptachlor epoxide and oxychlordane, intermediate for p,p′-DDT, and least for beta-hexachlorocyclohexane, p,p′-DDE, and trans-nonachlor. Mirex and dieldrin were not associated with total diabetes or pre-diabetes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
观海云远完成签到,获得积分10
2秒前
鲁彦华发布了新的文献求助30
3秒前
Jaychai完成签到,获得积分10
3秒前
3秒前
4秒前
豆包完成签到,获得积分10
4秒前
莫铭完成签到,获得积分10
4秒前
5秒前
小二郎应助zqt采纳,获得30
5秒前
5秒前
酷波er应助潘超宇采纳,获得10
5秒前
平常平松完成签到 ,获得积分20
6秒前
上官子默完成签到,获得积分10
7秒前
所所应助W9采纳,获得10
7秒前
7秒前
8秒前
木糖醇发布了新的文献求助10
8秒前
慕青应助李佳欣采纳,获得10
8秒前
liuuuuu发布了新的文献求助10
9秒前
9秒前
9秒前
SYLH应助飞云采纳,获得10
10秒前
live发布了新的文献求助10
11秒前
蹦蹦发布了新的文献求助10
11秒前
MCS发布了新的文献求助10
12秒前
轩辕德地完成签到,获得积分10
14秒前
devil发布了新的文献求助10
14秒前
轻轻完成签到,获得积分10
14秒前
15秒前
深情安青应助科研通管家采纳,获得10
16秒前
猪猪hero应助科研通管家采纳,获得10
16秒前
小二郎应助科研通管家采纳,获得10
16秒前
16秒前
17秒前
17秒前
17秒前
17秒前
17秒前
夕禾完成签到,获得积分20
17秒前
17秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance 500
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970120
求助须知:如何正确求助?哪些是违规求助? 3514810
关于积分的说明 11176124
捐赠科研通 3250136
什么是DOI,文献DOI怎么找? 1795198
邀请新用户注册赠送积分活动 875647
科研通“疑难数据库(出版商)”最低求助积分说明 804964