Abnormal Achromatic and Chromatic Contrast Sensitivity in Neurofibromatosis Type 1

消色差透镜 小细胞细胞 对比度(视觉) 色阶 听力学 神经纤维瘤病 空间频率 彩色视觉 心理学 医学 神经科学 光学 病理 物理 中枢神经系统
作者
Maria José Ribeiro,Inês R. Violante,Inês Bernardino,Fabiana Ramos,Jorge Saraiva,Pablo Reviriego,Meena Upadhyaya,Eduardo Silva,Miguel Castelo‐Branco
出处
期刊:Investigative Ophthalmology & Visual Science [Cadmus Press]
卷期号:53 (1): 287-287 被引量:19
标识
DOI:10.1167/iovs.11-8225
摘要

Purpose.: Neurofibromatosis type 1 (NF1) is a monogenic disorder with the majority of patients presenting subtle to moderate cognitive impairments. Visuospatial deficits are considered to be one of the hallmark characteristics of their cognitive profile. However, low-level visual processing has not been previously investigated. Our aim was to study contrast perception in these patients to assess the function of early visual areas. Methods.: Contrast sensitivity was tested in 19 children and adolescents with NF1 and 33 control children and adolescents and 12 adults with NF1 and 24 control adults. The tasks used probed two achromatic spatiotemporal frequency channels and chromatic red–green and blue–yellow pathways. Results.: Individuals with NF1 showed significant contrast sensitivity deficits for the achromatic higher spatial frequency channel [F (1,83) = 36.1, P < 0.001] and for the achromatic low spatial high temporal (magnocellular) frequency channel [F (1,72) = 8.0, P < 0.01]. Furthermore, individuals with NF1 presented a significant deficit in chromatic red–green (parvocellular) contrast sensitivity (P < 0.01) but not in blue–yellow (koniocelular) sensitivity. The decrease in achromatic sensitivity for higher spatial frequency was observed throughout the visual field, in both central and peripheral locations. In contrast, central contrast sensitivity for the magnocellular-biased condition was relatively preserved and only peripheral sensitivity was affected. Interestingly, the same pattern of deficits was found in both age groups tested. Conclusions.: These findings showed that contrast sensitivity is impaired in patients with NF1, associating for the first time abnormal low-level vision to the cognitive profile of this disorder.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
孟梦完成签到 ,获得积分10
1秒前
bc应助专注的盼兰采纳,获得10
3秒前
3秒前
澡雪发布了新的文献求助10
4秒前
4秒前
赘婿应助呆萌的延恶采纳,获得10
4秒前
hahaer发布了新的文献求助10
5秒前
Orange应助瘦瘦的元容采纳,获得10
5秒前
7秒前
6666发布了新的文献求助10
7秒前
CipherSage应助Haho采纳,获得10
10秒前
lingua完成签到,获得积分10
10秒前
至幸发布了新的文献求助10
10秒前
Halo完成签到,获得积分10
10秒前
tttt发布了新的文献求助10
11秒前
13秒前
yuyyyi完成签到,获得积分10
13秒前
SQzy完成签到,获得积分10
15秒前
15秒前
15秒前
生动的天亦完成签到,获得积分10
17秒前
wanglong0118发布了新的文献求助10
17秒前
一路硕博完成签到,获得积分10
17秒前
123发布了新的文献求助10
18秒前
木香发布了新的文献求助30
20秒前
啦啦啦完成签到 ,获得积分10
22秒前
蘑菇丰收发布了新的文献求助150
23秒前
所所应助Self-made采纳,获得10
24秒前
天天快乐应助wanglong0118采纳,获得10
24秒前
24秒前
26秒前
小蘑菇应助苗苗采纳,获得10
27秒前
28秒前
31秒前
柴圆滚滚发布了新的文献求助10
31秒前
33秒前
今后应助姜雪采纳,获得30
34秒前
34秒前
34秒前
34秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975426
求助须知:如何正确求助?哪些是违规求助? 3519848
关于积分的说明 11199831
捐赠科研通 3256122
什么是DOI,文献DOI怎么找? 1798124
邀请新用户注册赠送积分活动 877386
科研通“疑难数据库(出版商)”最低求助积分说明 806305