Abnormal Achromatic and Chromatic Contrast Sensitivity in Neurofibromatosis Type 1

消色差透镜 小细胞细胞 对比度(视觉) 色阶 听力学 神经纤维瘤病 空间频率 彩色视觉 心理学 医学 神经科学 光学 病理 物理 中枢神经系统
作者
Maria José Ribeiro,Inês R. Violante,Inês Bernardino,Fabiana Ramos,Jorge Saraiva,Pablo Reviriego,Meena Upadhyaya,Eduardo Silva,Miguel Castelo‐Branco
出处
期刊:Investigative Ophthalmology & Visual Science [Cadmus Press]
卷期号:53 (1): 287-287 被引量:19
标识
DOI:10.1167/iovs.11-8225
摘要

Purpose.: Neurofibromatosis type 1 (NF1) is a monogenic disorder with the majority of patients presenting subtle to moderate cognitive impairments. Visuospatial deficits are considered to be one of the hallmark characteristics of their cognitive profile. However, low-level visual processing has not been previously investigated. Our aim was to study contrast perception in these patients to assess the function of early visual areas. Methods.: Contrast sensitivity was tested in 19 children and adolescents with NF1 and 33 control children and adolescents and 12 adults with NF1 and 24 control adults. The tasks used probed two achromatic spatiotemporal frequency channels and chromatic red–green and blue–yellow pathways. Results.: Individuals with NF1 showed significant contrast sensitivity deficits for the achromatic higher spatial frequency channel [F (1,83) = 36.1, P < 0.001] and for the achromatic low spatial high temporal (magnocellular) frequency channel [F (1,72) = 8.0, P < 0.01]. Furthermore, individuals with NF1 presented a significant deficit in chromatic red–green (parvocellular) contrast sensitivity (P < 0.01) but not in blue–yellow (koniocelular) sensitivity. The decrease in achromatic sensitivity for higher spatial frequency was observed throughout the visual field, in both central and peripheral locations. In contrast, central contrast sensitivity for the magnocellular-biased condition was relatively preserved and only peripheral sensitivity was affected. Interestingly, the same pattern of deficits was found in both age groups tested. Conclusions.: These findings showed that contrast sensitivity is impaired in patients with NF1, associating for the first time abnormal low-level vision to the cognitive profile of this disorder.
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