Malignant Glomus Tumor of the Leg Developed in the Context of a Superficial Typical Glomus Tumor

血管球瘤 病理 波形蛋白 免疫组织化学 核异型性 结核(地质) 血管球细胞 背景(考古学) 异型性 细胞质 生物 解剖 医学 细胞生物学 受体 古生物学 生物化学 化学受体
作者
Luca Lancerotto,Roberto Salmaso,Leonardo Sartore,Franco Bassetto
出处
期刊:International Journal of Surgical Pathology [SAGE]
卷期号:20 (4): 420-424 被引量:7
标识
DOI:10.1177/1066896911432454
摘要

A 41-year-old man presented with a 2-cm painful subcutaneous nodule in his right leg, which had been present for more than 10 years and was recently enlarging. Histologically, the tumor was composed of sheets and nests of cells with variable cytomorphology, including typical round/ovoid glomus cells with clear cytoplasm and well-defined borders, small cells, and spindle cells. Numerous medium to large vessels were present. Nodules with moderate to high cellularity, nuclear atypia, and frequent mitotic figures (42 per 50 high-power fields) were noted. Immunohistochemistry showed cytoplasmic and membranous expression of smooth-muscle actin, vimentin, and membranous expression of type IV collagen. Whereas superficiality, dimensions, and long-term follow-up may suggest classification as a symplastic or uncertain potential glomus tumor (GT), histological features and immunoprofile are indicative of malignant nodules developed in a typical GT. The follow-up has been negative for recurrence/metastases. A search of the literature revealed 17 cases of malignant GTs between 1995 and 2010, all fatal, of which 10 had skin as the primary site.

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