2-D photonic crystal based Bio-chip for DNA analysis of breast cancer

The work is basically focused on the Design and simulation of Bio-chip based Optical Sensor for the DNA analysis. In medical science it has been observed that the physical agents or errors in DNA replication alter the usual DNA sequence causing cancer and other genetic diseases. It takes 5–7 years for a normal cell to become cancerous. 70% of the cancer conditions that are detected are at the advanced stage. In this paper we have demonstrated a Nano-platform based chip which is highly sensitive for the change in refractive index and thus can easily differentiate the normal and cancerous DNA. Computation has been done by using the tool of MEEP & MPB by using FDTD algorithm. An analysis of normal cell breast DNA and Breast Cancer cell DNA has been done. The obtained spectral behavior shows the maximum amplitude for normal breast DNA is 0.1802 where as for benign DNA and malignant DNA is 0.1791 and 0.1795 respectively. The wavelength shifts were also observed for normal breast DNA at 1.845 um and benign DNA at1.846 um and malignant DNA at 1.8447 um. The quality factor of the proposed design is 118563 and a sensitivity of 10 ⁻⁶ . Further the proposed chip design for the fabrication is possible by doing the layout GDSII file format and IMEC IPKISS tool.