Endoscopic submucosal dissection is superior to conventional endoscopic resection as a curative treatment for early squamous cell carcinoma of the esophagus (with video)

医学 内镜黏膜下剥离术 穿孔 食管 回顾性队列研究 外科 粘膜切除术 贲门失弛缓症 内窥镜检查 冶金 材料科学 冲孔
作者
Hiroaki Takahashi,Yoshiaki Arimura,Masao Hosokawa,Satoshi Okahara,Tokuma Tanuma,Junichi Kodaira,Hidetoshi Kagaya,Yuichi Shimizu,Kaku Hokari,Hiroyuki Tsukagoshi,Yasuhisa Shinomura,Masahiro Fujita
出处
期刊:Gastrointestinal Endoscopy [Elsevier BV]
卷期号:72 (2): 255-264.e2 被引量:322
标识
DOI:10.1016/j.gie.2010.02.040
摘要

Background Endoscopic submucosal dissection (ESD) was originally developed in Japan for en bloc resection of gastric neoplasms. Objective To clarify whether the novel ESD procedure is feasible and gives results that justify the pursuit of integrated minimally invasive procedures aimed at curing early squamous cell carcinoma of the esophagus (SCCE). Design Retrospective cohort study. Setting A single-institution trial by experienced endoscopists. Patients This study involved 300 consecutively enrolled patients with SCCE (Tumor, Nodes, Metastasis classification T1, N0) who underwent either EMR (n = 184) or ESD (n = 116) from March 1994 to July 2007. Intervention The patients underwent endoscopic resection and then were followed by periodic endoscopy for 8 to 174 months (mean 65 months). Main Outcome Measurements Resectability, cure rates, complications, disease-free survival of the two groups, and risk factors for local recurrence were explored. Results En bloc resection and the local recurrence rate were significantly better in the ESD group ( P = .0009 and .065, respectively). The frequency of perforation was not significantly different between the two groups ( P = .68). Four independent risk factors for local recurrence were identified by the Cox regression model: EMR, deep cancer invasion, upper esophagus location, and family history of esophageal cancer. Radical cure is mostly obtained by successful endoscopic retreatment of local recurrence after previous endoscopic resection. Disease-free survival was significantly better with ESD. Limitations The study's retrospective nature prevents definitive conclusions. Conclusions We provide evidence that ESD gives a higher cure rate and is safer than conventional endoscopic resection when applied to early SCCE. ESD warrants prospective comparative studies with conventional endoscopic resection.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
英俊的铭应助tfq200采纳,获得10
1秒前
ky完成签到,获得积分10
3秒前
4秒前
FashionBoy应助苏苏没有可乐采纳,获得10
4秒前
不敢装睡完成签到,获得积分10
7秒前
伊笙完成签到 ,获得积分0
8秒前
8秒前
量子星尘发布了新的文献求助10
10秒前
玺青一生完成签到 ,获得积分10
13秒前
高速旋转老沁完成签到 ,获得积分10
17秒前
凉拌冰阔落完成签到 ,获得积分10
17秒前
郑zhenglanyou完成签到 ,获得积分10
18秒前
沉静的清涟完成签到,获得积分10
20秒前
一条摆摆的沙丁鱼完成签到 ,获得积分10
21秒前
啊哈哈哈哈哈完成签到 ,获得积分10
22秒前
22秒前
情怀应助yyy采纳,获得10
25秒前
量子星尘发布了新的文献求助10
27秒前
28秒前
28秒前
愛研究完成签到,获得积分10
29秒前
光之美少女完成签到 ,获得积分10
30秒前
微笑的若魔完成签到 ,获得积分10
31秒前
123456完成签到 ,获得积分10
32秒前
33秒前
严究生发布了新的文献求助10
35秒前
村长热爱美丽完成签到 ,获得积分10
38秒前
豆豆完成签到 ,获得积分10
40秒前
科研木头人完成签到 ,获得积分10
40秒前
41秒前
42秒前
Sleven完成签到,获得积分10
43秒前
量子星尘发布了新的文献求助10
47秒前
Alisan完成签到,获得积分10
49秒前
吴总完成签到 ,获得积分10
50秒前
Ying完成签到,获得积分10
53秒前
leaolf应助科研通管家采纳,获得10
53秒前
NexusExplorer应助科研通管家采纳,获得10
53秒前
香蕉觅云应助发发旦旦采纳,获得10
55秒前
Dellamoffy完成签到,获得积分10
55秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
计划经济时代的工厂管理与工人状况(1949-1966)——以郑州市国营工厂为例 500
Comparison of spinal anesthesia and general anesthesia in total hip and total knee arthroplasty: a meta-analysis and systematic review 500
INQUIRY-BASED PEDAGOGY TO SUPPORT STEM LEARNING AND 21ST CENTURY SKILLS: PREPARING NEW TEACHERS TO IMPLEMENT PROJECT AND PROBLEM-BASED LEARNING 500
Modern Britain, 1750 to the Present (第2版) 300
Writing to the Rhythm of Labor Cultural Politics of the Chinese Revolution, 1942–1976 300
Lightning Wires: The Telegraph and China's Technological Modernization, 1860-1890 250
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 物理化学 基因 催化作用 遗传学 冶金 电极 光电子学
热门帖子
关注 科研通微信公众号,转发送积分 4597530
求助须知:如何正确求助?哪些是违规求助? 4009101
关于积分的说明 12409876
捐赠科研通 3688331
什么是DOI,文献DOI怎么找? 2033101
邀请新用户注册赠送积分活动 1066366
科研通“疑难数据库(出版商)”最低求助积分说明 951605