Comparative study of photodynamic therapy vs. CO2laser vaporization in treatment of condylomata acuminata, a randomized clinical trial

British Journal of DermatologyVolume 156, Issue 3 p. 516-520 Comparative study of photodynamic therapy vs. CO2 laser vaporization in treatment of condylomata acuminata, a randomized clinical trial K. Chen, K. Chen Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 14 Jiangwangmiao Road, Nanjing 210042, ChinaSearch for more papers by this authorB.Z. Chang, B.Z. Chang Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 14 Jiangwangmiao Road, Nanjing 210042, ChinaSearch for more papers by this authorM. Ju, M. Ju Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 14 Jiangwangmiao Road, Nanjing 210042, ChinaSearch for more papers by this authorX.H. Zhang, X.H. Zhang Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 14 Jiangwangmiao Road, Nanjing 210042, ChinaSearch for more papers by this authorH. Gu, H. Gu Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 14 Jiangwangmiao Road, Nanjing 210042, ChinaSearch for more papers by this author K. Chen, K. Chen Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 14 Jiangwangmiao Road, Nanjing 210042, ChinaSearch for more papers by this authorB.Z. Chang, B.Z. Chang Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 14 Jiangwangmiao Road, Nanjing 210042, ChinaSearch for more papers by this authorM. Ju, M. Ju Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 14 Jiangwangmiao Road, Nanjing 210042, ChinaSearch for more papers by this authorX.H. Zhang, X.H. Zhang Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 14 Jiangwangmiao Road, Nanjing 210042, ChinaSearch for more papers by this authorH. Gu, H. Gu Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 14 Jiangwangmiao Road, Nanjing 210042, ChinaSearch for more papers by this author First published: 12 December 2006 https://doi.org/10.1111/j.1365-2133.2006.07648.xCitations: 97 Heng Gu.E-mail: guhengy@yahoo.com.cn Conflicts of interest None declared. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Summary Background Most conventional therapies for condylomata acuminata (CA) are traumatic and have high recurrence rates. Objectives To investigate the efficacy and safety of topical application of 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) for the treatment of CA. Methods Sixty-five patients with CA were allocated into the treatment (ALA-PDT) group and treated with 20% ALA solution under occlusive dressing for 3 h followed by irradiation with the helium–neon laser at a dose of 100 J cm−2 and a power of 100 mW. Another 21 CA patients were allocated into the control group and treated with the CO2 laser. The treatment was to be repeated 1 week later if the lesion was not completely removed after the first treatment. Results After one treatment, the complete removal rate was 95% in the ALA-PDT group and 100% in the control group. After two treatments with ALA-PDT, the complete removal rate in the treatment group was 100%. The recurrence rate for ALA-PDT group was 6·3% which was significantly lower than that in control group (19·1%, P < 0·05). Moreover, the proportion of patients with adverse effects in the ALA-PDT group (13·9%) was also significantly lower than that in control group (100%, P < 0·05). The side-effects in patients treated with ALA-PDT mainly included mild burning and/or stinging restricted to the illuminated area. Conclusions The present study shows that topical application of ALA-PDT is a simpler, more effective and safer therapy with a lower recurrence for treatment of CA compared with conventional CO2 laser therapy. Citing Literature Volume156, Issue3March 2007Pages 516-520 RelatedInformation