化学
终端(电信)
碘化物
反应性(心理学)
组合化学
镉
炔丙基
有机合成
有机化学
计算机科学
催化作用
医学
电信
病理
替代医学
作者
Xinjun Tang,Can Zhu,Tao Cao,Jingqiang Kuang,Weilong Lin,Shengjun Ni,Jiasheng Zhang,Shengming Ma
摘要
Allenes are important building blocks in organic synthesis and have attracted much attention from researchers worldwide. So far, mono- and 1,3-disubstituted allenes can be prepared easily by applying the allenylation of terminal alkynes reaction of aldehydes. However, trisubstituted allenes have never been reported using this reaction due to the extremely low reactivity of ketones. Here, we report the one-pot synthesis of trisubstituted allenes from terminal alkynes and ketones utilizing cadmium iodide as the mediator. With this protocol, a series of different allenes, including 1,5-bisallenes and optically active allenols, which are especially important in synthetic chemistry, have been successfully prepared.
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