肿胀 的
星形胶质细胞
四乙基铵
化学
谷氨酸受体
生物物理学
哇巴因
生物化学
钾
钠
内分泌学
生物
材料科学
中枢神经系统
复合材料
受体
有机化学
作者
Alex S. Bender,Arne Schousboe,Winfried Reichelt,Michael D. Norenberg
标识
DOI:10.1002/(sici)1097-4547(19980501)52:3<307::aid-jnr7>3.0.co;2-h
摘要
L-Glutamate (L-GLU) induced astrocyte swelling in a time- and concentration-dependent, as well as Na+- and Ca2+-dependent, and Cl(-)-independent manner. Swelling was prevented by MK-801, cystine, and ouabain. Since L-GLU swelling is ionically dependent, we determined the role of various ions in such swelling. Our results indicate that K+ uptake plays a major role in the mechanism of L-GLU-induced astrocyte swelling. Like swelling, K+ uptake is dependent on Ca2+ and Na+, but not on Cl-. Likewise, K+ uptake was inhibited by MK-801, cystine, and ouabain. The K+ channel blockers, Ba2+ and tetraethylammonium, partially prevented L-GLU-induced swelling. In addition to K+ channels, K+ influx may also be mediated through Na+/K+-ATPase, as its activity is increased by L-GLU uptake along with the required Na+. Taken together, the data suggest that K+ influx plays a key role in the mechanism of L-GLU-mediated astrocyte swelling.
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