Human Gut-Specific Homeostatic Dendritic Cells Are Generated from Blood Precursors by the Gut Microenvironment

BackgroundDendritic cells (DC) dictate not only the type of T-cell immunity, but also homing patterns of T cells in mice. In humans, we characterized normal human gut DC and tested whether gut-specific homeostatic DC could be generated from blood precursors by factors in the gut microenvironment.