Revised Cutaneous Lupus Erythematosus Disease Area and Severity Index (RCLASI): a modified outcome instrument for cutaneous lupus erythematosus

British Journal of DermatologyVolume 163, Issue 1 p. 83-92 CLINICAL AND LABORATORY INVESTIGATIONS Revised Cutaneous Lupus Erythematosus Disease Area and Severity Index (RCLASI): a modified outcome instrument for cutaneous lupus erythematosus Correction(s) for this article Errata Volume 163Issue 4British Journal of Dermatology pages: 898-899 First Published online: September 20, 2010 A. Kuhn, A. Kuhn Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorS. Amler, S. Amler Department of Medical Informatics and Biomathematics, University of Münster, Münster, GermanySearch for more papers by this authorS. Beissert, S. Beissert Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorM. Böhm, M. Böhm Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorR. Brehler, R. Brehler Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorJ. Ehrchen, J. Ehrchen Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorS. Grundmann, S. Grundmann Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorM. Haust, M. Haust Department of Dermatology, University of Düsseldorf, Düsseldorf, GermanySearch for more papers by this authorV. Ruland, V. Ruland Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorM. Schiller, M. Schiller Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorP. Schulz, P. Schulz Department of Dermatology, Fachklinik Bad Bentheim, Bad Bentheim, GermanySearch for more papers by this authorS. Ständer, S. Ständer Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorC. Sauerland, C. Sauerland Department of Medical Informatics and Biomathematics, University of Münster, Münster, GermanySearch for more papers by this authorT.A. Luger, T.A. Luger Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorG. Bonsmann, G. Bonsmann Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this author A. Kuhn, A. Kuhn Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorS. Amler, S. Amler Department of Medical Informatics and Biomathematics, University of Münster, Münster, GermanySearch for more papers by this authorS. Beissert, S. Beissert Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorM. Böhm, M. Böhm Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorR. Brehler, R. Brehler Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorJ. Ehrchen, J. Ehrchen Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorS. Grundmann, S. Grundmann Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorM. Haust, M. Haust Department of Dermatology, University of Düsseldorf, Düsseldorf, GermanySearch for more papers by this authorV. Ruland, V. Ruland Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorM. Schiller, M. Schiller Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorP. Schulz, P. Schulz Department of Dermatology, Fachklinik Bad Bentheim, Bad Bentheim, GermanySearch for more papers by this authorS. Ständer, S. Ständer Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorC. Sauerland, C. Sauerland Department of Medical Informatics and Biomathematics, University of Münster, Münster, GermanySearch for more papers by this authorT.A. Luger, T.A. Luger Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this authorG. Bonsmann, G. Bonsmann Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanySearch for more papers by this author First published: 24 June 2010 https://doi.org/10.1111/j.1365-2133.2010.09799.xCitations: 73 Annegret Kuhn.E-mail: kuhnan@uni-muenster.de Conflicts of interestThe authors declare no conflict of interest. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Summary Background In 2005, a scoring system (CLASI, Cutaneous Lupus Erythematosus Disease Area and Severity Index) was developed for patients with cutaneous lupus erythematosus (CLE) to assess disease 'activity' and 'damage'. However, the CLASI does not give an accurate assessment of the severity in all disease subtypes. Objectives The main objective of this study was to analyse critically the included parameters of the CLASI and to revise the activity and damage score taking into account various clinical features of the different subtypes of CLE. The revised CLASI (RCLASI) was also validated for use in clinical trials. Patients and methods A RCLASI was designed with regard to the anatomical region (i.e. face, chest, arms) and morphological aspects (i.e. erythema, scaling/hyperkeratosis, oedema/infiltration, scarring/atrophy) of skin lesions and evaluated by nine dermatologists who scored 12 patients with different subtypes of CLE to estimate inter- and intrarater reliability. Results Reliability studies demonstrated an intraclass correlation coefficient (ICC) for an inter-rater reliability of 0·89 for the activity score [95% confidence interval (CI) 0·79–0·96] and of 0·79 for the damage score (95% CI 0·62–0·92). The ICC for intrarater reliability for the activity score was 0·92 (95% CI 0·89–0·95) and the ICC for the damage score was 0·95 (95% CI 0·92–0·98). Conclusions In the present study, a RCLASI was developed by experts, and reliability studies supported the validity and applicability of the revised scoring instrument for CLE. Thus, the RCLASI is a valuable instrument in multicentre studies and for the clinical evaluation of activity and damage in different disease subtypes. Citing Literature Volume163, Issue1July 2010Pages 83-92 RelatedInformation