细胞毒性T细胞
CD28
T细胞
抗原提呈细胞
离子霉素
生物
细胞生物学
免疫系统
化学
分子生物学
抗原
干扰素γ
CD8型
免疫学
生物化学
细胞内
体外
作者
Andrei I. Chapoval,Jian Ni,Julie S. Lau,Ryan A. Wilcox,Dallas B. Flies,Ding Liu,Haidong Dong,Gabriel L. Sica,Gefeng Zhu,Koji Tamada,Lieping Chen
摘要
We describe here a newly identified member of the human B7 family, designated B7 homolog 3 (B7-H3), that shares 20-27% amino acid identity with other B7 family members. B7-H3 mRNA is not detectable in peripheral blood mononuclear cells, although it is found in various normal tissues and in several tumor cell lines. Expression of B7-H3 protein, however, can be induced on dendritic cells (DCs) and monocytes by inflammatory cytokines and a combination of phorbol myristate acetate (PMA) + ionomycin. Soluble B7-H3 protein binds a putative counter-receptor on activated T cells that is distinct from CD28, cytotoxic T lymphocyte antigen 4 (CTLA-4), inducible costimulator (ICOS) and PD-1. B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells, enhances the induction of cytotoxic T cells and selectively stimulates interferon gamma (IFN-gamma) production in the presence of T cell receptor signaling. In contrast, inclusion of antisense B7-H3 oligonucleotides decreases the expression of B7-H3 on DCs and inhibits IFN-gamma production by DC-stimulated allogeneic T cells.Thus, we describe a newly identified costimulatory pathway that may participate in the regulation of cell-mediated immune responses.
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