化学
环糊精
对映体
色谱法
硅胶
固定相
相(物质)
高效液相色谱法
β-环糊精
BETA(编程语言)
手性固定相
手性柱色谱法
反相色谱法
有机化学
计算机科学
程序设计语言
作者
Apryll M. Stalcup,San Chun. Chang,Daniel W. Armstrong,Josef Pitha
标识
DOI:10.1016/s0021-9673(01)89435-8
摘要
(S)-2- and (R,S)-2-hydroxypropyl-beta-cyclodextrin have been bonded to silica gel and evaluated as stationary phases for reversed-phase liquid chromatography. Stationary phases also were prepared on two silicas having different pore sizes and surface areas. Dissimilarities were observed in enantiomeric selectivities between these columns and also between these and the native beta-cyclodextrin columns. With the exception of compounds 5 and 10, all other racemates reported here which have been successfully resolved on the new phases are enantiomers which have not been previously reported as separated on the beta-cyclodextrin stationary phase. In some cases, there were also differences in enantioselectivities observed between the (S)- and the (R,S)-hydroxypropyl-beta-cyclodextrin phases on the same silica. The results are discussed in terms of the retention mechanism and compared to results reported earlier for beta-cyclodextrin columns.
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