Every 15-Min Delay in Recanalization by Intra-Arterial Therapy in Acute Ischemic Stroke Increases Risk of Poor Outcome

医学 冲程(发动机) 内科学 结果(博弈论) 心脏病学 缺血性中风 缺血 数理经济学 数学 机械工程 工程类
作者
Anna He,Leonid Churilov,Peter Mitchell,Richard Dowling,Bernard Yan
出处
期刊:International Journal of Stroke [SAGE Publishing]
卷期号:10 (7): 1062-1067 被引量:38
标识
DOI:10.1111/ijs.12495
摘要

Intra-arterial therapy has improved recanalization rates compared with intravenous thrombolysis for acute ischemic stroke; however, superior clinical efficacy has not been convincingly demonstrated. Time to recanalization is postulated as a mechanism hindering the efficacy of intra-arterial therapy.To investigate the effects of time to recanalization on clinical outcome postintra-arterial therapy for acute ischemic stroke.Clinical data were collected prospectively for consecutive patients undergoing intra-arterial therapy for acute ischemic stroke at a single center between 2009 and 2013. Ninety-day functional outcome was assessed by the modified Rankin scale. Univariate analyses identified candidate clinical variables for inclusion in the multivariable model; multivariable logistic regression analyses identified variables independently associated with good outcome, defined as modified Rankin scale 0-2.One hundred and seven patients were included in the analysis. Median (interquartile range) age was 67 (54-77) years, 41 (38%) were female, and median (interquartile range) baseline National Institute of Health Stroke Severity score was 18 (13-22). Median time from symptom onset to recanalization was 330 min (interquartile range 277-397). Fifty-four (50%) patients achieved a favorable modified Rankin scale at 90 days. Age, successful recanalization, and time to recanalization were independently associated with good outcome at 90 days in multivariable logistic regression analysis. For every 15 min delay in recanalization, the odds of good outcome decreased by 10%.Longer time to recanalization was associated with poorer functional outcome post intra-arterial therapy. We recommend that a systematic approach to minimize time delay to treatment is warranted in intra-arterial therapy for acute ischemic stroke.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Chem34完成签到,获得积分10
5秒前
7秒前
量子星尘发布了新的文献求助10
7秒前
hhh2018687完成签到,获得积分10
7秒前
7秒前
8秒前
8秒前
8秒前
8秒前
9秒前
9秒前
9秒前
9秒前
9秒前
9秒前
9秒前
嘒彼小星完成签到 ,获得积分10
9秒前
9秒前
10秒前
10秒前
10秒前
10秒前
11秒前
ri_290完成签到,获得积分10
11秒前
12秒前
nsc发布了新的文献求助30
14秒前
nsc发布了新的文献求助10
14秒前
nsc发布了新的文献求助10
14秒前
nsc发布了新的文献求助10
14秒前
nsc发布了新的文献求助10
14秒前
nsc发布了新的文献求助10
14秒前
nsc发布了新的文献求助10
14秒前
nsc发布了新的文献求助10
14秒前
nsc发布了新的文献求助10
14秒前
nsc发布了新的文献求助10
14秒前
nsc发布了新的文献求助10
14秒前
nsc发布了新的文献求助10
14秒前
nsc发布了新的文献求助30
14秒前
nsc发布了新的文献求助10
14秒前
nsc发布了新的文献求助10
14秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038039
求助须知:如何正确求助?哪些是违规求助? 3575756
关于积分的说明 11373782
捐赠科研通 3305574
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022