表观遗传学
神经科学
神经营养因子
心理学
萧条(经济学)
脑源性神经营养因子
抗抑郁药
神经病理学
原肌球蛋白受体激酶B
消光(光学矿物学)
医学
海马体
生物
内科学
疾病
遗传学
基因
经济
古生物学
受体
宏观经济学
作者
Chi Him Poon,Boon Chin Heng,Lee Wei Lim
摘要
Abstract Advances in characterizing molecular profiles provide valuable insights and opportunities for deciphering the neuropathology of depression. Although abnormal brain‐derived neurotrophic factor (BDNF) expression in depression has gained much support from preclinical and clinical research, how it mediates behavioral alterations in the depressed state remains largely obscure. Environmental factors contribute significantly to the onset of depression and produce robust epigenetic changes. Epigenetic regulation of BDNF , as one of the most characterized gene loci in epigenetics, has recently emerged as a target in research on memory and psychiatric disorders. Specifically, epigenetic alterations of BDNF exons are heavily involved in mediating memory functions and antidepressant effects. In this review, we discuss key research on stress‐induced depression from both preclinical and clinical studies, which revealed that differential epigenetic regulation of specific BDNF exons is associated with depression pathophysiology. Considering that BDNF has a central role in depression, we argue that memory extinction, an adaptive response to fear exposure, is dependent on BDNF modulation and holds promise as a prospective target for alleviating or treating depression and anxiety disorders.
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