医学
胎盘早剥
病历
医疗补助
子痫前期
药物流行病学
怀孕
置信区间
产科
算法
胎龄
儿科
医疗保健
胎儿
内科学
药方
药理学
经济
生物
遗传学
经济增长
计算机科学
作者
Min He,Krista F. Huybrechts,Sara Z. Dejene,Loreen Straub,Devan Bartels,Stacey Burns,David J. Combs,Jennifer Cottral,Kathryn J. Gray,Beryl Manning‐Geist,Helen Mogun,Rebecca Reimers,Sonia Hernández–Dı́az,Brian T. Bateman
摘要
Abstract Background The Medicaid Analytic eXtract (MAX) is a health care utilization database from publicly insured individuals that has been used for studies of drug safety in pregnancy. Claims‐based algorithms for defining many important maternal and neonatal outcomes have not been validated. Objective To validate claims‐based algorithms for identifying selected pregnancy outcomes in MAX using hospital medical records. Methods The medical records of mothers who delivered between 2000 and 2010 within a single large healthcare system were linked to their claims in MAX. Claims‐based algorithms for placental abruption, preeclampsia, postpartum hemorrhage, small for gestational age, and noncardiac congenital malformation were defined. Fifty randomly sampled cases for each outcome identified using these algorithms were selected, and their medical records were independently reviewed by two physicians to confirm the presence of the diagnosis of interest; disagreements were resolved by a third physician reviewer. Positive predictive values (PPVs) and 95% confidence intervals (CIs) of the claims‐based algorithms were calculated using medical records as the gold standard. Results The linked cohort included 10,899 live‐birth pregnancies. The PPV was 92% (95% CI, 82%‐97%) for placental abruption, 82% (95% CI, 70%‐91%) for preeclampsia, 74% (95% CI, 61%‐85%) for postpartum hemorrhage, 92% (95% CI, 82%‐97%) for small for gestational age, and 86% (95% CI, 74%‐94%) for noncardiac congenital malformation. Conclusions Across the perinatal outcomes considered, PPVs ranged between 74% and 92%. These PPVs can inform bias analyses that correct for outcome misclassification.
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