自愈水凝胶
材料科学
聚氨酯
伤口敷料
伤口愈合
粘附
胶粘剂
自愈
组织粘连
肿胀 的
互穿聚合物网络
生物医学工程
聚合物
复合材料
高分子化学
外科
替代医学
图层(电子)
病理
医学
作者
Yi Hou,Nan Jiang,Dan Sun,Yiping Wang,Xianchun Chen,Songsong Zhu,Li Zhang
出处
期刊:RSC Advances
[The Royal Society of Chemistry]
日期:2020-01-01
卷期号:10 (9): 4907-4915
被引量:40
摘要
Hydrogels demonstrate superior properties that favor wound healing and have been widely used in clinical settings for wound dressing applications. However, commercial hydrogel dressings often lack flexibility/adhesiveness, and do not conform well to the irregular skin surfaces of complex wounds and/or wounds near joints. As a result, the wound is likely to be exposed to potential bacterial invasion. Herein, we designed and developed a mechanically flexible and self-adhesive polyurethane-poly(acrylamide) (PU-PAAm) hydrogel for wound healing applications. The hydrogel can be cured from a novel waterborne emulsion within 90 s under UV irradiation. The PU component within the PU-PAAm hydrogel plays a "bridging" role that accelerates the formation of an interpenetrating polymer network (IPN), which consists of a physically crosslinked PU network trapped within a chemically crosslinked PAAm network. The unique IPN structure endowes the hydrogel with superior stretchability and ductility. The hydrogen bonding formation and electrostatic interaction between the hydrogel and skin ensure strong adhesion without causing irritation to skin upon dressing removal. Animal studies further confirmed the PU-PAAm hydrogel's remarkable skin regeneration capability. This work shows our new hydrogel holds a promising prospect for treatment of complicated or challenging wounds such as burns and chronic wounds.
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