医学
骨关节炎
槲皮素
肿瘤坏死因子α
白细胞介素
作用机理
组织病理学
药理学
治疗效果
受体
污渍
内科学
内分泌学
病理
细胞因子
体外
化学
生物化学
替代医学
基因
抗氧化剂
作者
Jun Zhang,Jing Yin,Daohong Zhao,Chaoran Wang,Yuhao Zhang,Yingsong Wang,Tao Li
标识
DOI:10.1177/0300060519873461
摘要
Objective To study the therapeutic effect and mechanism of action of quercetin in a rat model of osteoarthritis (OA). Methods The OA rat model was established by intra-articular injection of papain. Changes in knee diameter, toe volume and histopathology were measured. Levels of interleukin (IL)-β and tumor necrosis factor (TNF)-α were assessed by ELISA. Relative expression of Toll-like receptor (TLR)-4 and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) was evaluated by western blotting. Results Compared with rats treated with papain alone, changes in knee diameter, toe volume and Makin' s score were less apparent in OA rats treated with quercetin. Levels of serum IL-1β and TNF-α were also reduced in quercetin-treated OA rats. Expression of TLR-4 and NF-κB was significantly suppressed in a dose-dependent manner in quercetin-treated OA rats. Conclusion Quercetin exhibited a therapeutic effect in OA rats, which may be related to inhibition of IL-1β and TNF-α production via the TLR-4/NF-κB pathway.
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