Application value of adjuvant inhalation of hyperbaric oxygen in viability and life quality of postoperative patients with malignant gliomas

Objective To explore the influence of chemoradiotherapy combined with inhalation of hyperbaric oxygen in short-term therapeutic effectiveness,viability and quality of life of postoperative patients with malignant gliomas.Methods A total of 86 patients with malignant gliomas,admitted to our hospital from January 2009 to December 2013,were chosen in our study; according to the wishes of patients and their families,all patients were divided into two groups:chemoradiotherapy combined with inhalation of hyperbaric oxygen group (n=47) and chemoradiotherapy group (n=39).Chemotherapy regimens were given:temozolomide of 150 mg/m2 body surface area at the first period once daily for a consecutive five days and temozolomide of 200 mg/m2 body surface area since the second period once daily for consecutive five days.Hyperbaric oxygen therapy was given with duration of 60 min at pressure of 2.8 atm.Conventional radiotherapy (6000 cGy/30F) was given in both groups.WHO established solid tumor chemosensitivity criteria was used to evaluate the effective rate of total symptoms,and activity of daily living (ADL) scale and F-36 scale were employed to evaluate the viability and life quality before and three and six months after the intervention.Results The effective rate of total symptoms,ratio of ADL＞60 points in chemoradiotherapy combined with inhalation of hyperbaric oxygen group 3 and 6 months after treatment were 95.74 ％,53.2％ and 72.3％,which were significantly higher than those in the chemoradiotherapy group (58.97 ％,30.8％ and 48.7％,P＜0.05).The scores of all the items of SF-36 scale in chemoradiotherapy combined with inhalation of hyperbaric oxygen group 3 and 6 months after treatment were significantly higher than those in the chemoradiotherapy group (P＜0.05).Conclusion Inhalation of hyperbaric oxygen can significantly improve short-term therapeutic effectiveness,survival duration,viability and quality of life of postoperative patients with malignant gliomas,and obviously improve the prognosis of patients. Key words: Glioma;  Chemomdiotherapy;  Hyperbaric oxygen;  Viability;  Life quality